3-[3-(Trifluoromethyl)phenoxy]azetidine hydrochloride

Base Information

• Chemical Name: 3-[3-(Trifluoromethyl)phenoxy]azetidine hydrochloride
• CAS No.: 1188374-88-0
• Molecular Formula: C10H10F3NO^.HCl
• Molecular Weight: 253.652
• Hs Code.: 2933990090
• Mol file: 1188374-88-0.mol

Synonyms:Azetidine, 3-[3-(trifluoromethyl)phenoxy]-, hydrochloride (1:1);

Chemical Property of 3-[3-(Trifluoromethyl)phenoxy]azetidine hydrochloride

Chemical Property:

• PSA: 21.26000
• LogP: 3.18680
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%min ^*data from raw suppliers

3-[3-(Trifluoromethyl)phenoxy]azetidineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-[3-(Trifluoromethyl)phenoxy]azetidine hydrochloride

There total 2 articles about 3-[3-(Trifluoromethyl)phenoxy]azetidine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(Diphenylmethyl)-3-[3-(trifluoromethyl)phenoxy] azetidine → 3-[3-(trifluoromethyl)phenoxy]azetidine hydrochloride (1188374-88-0)

Guidance literature:

With hydrogen; palladium(II) hydroxide; In ethanol; for 7h;

Reference yield:

tert-butyl 3-(3-(trifluoromethyl)phenoxy)azetidine-1-carboxylate (954232-85-0) → 3-[3-(trifluoromethyl)phenoxy]azetidine hydrochloride (1188374-88-0)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane;

DOI:10.1016/j.bmcl.2010.10.107

Reference yield: 92.0%

3-[3-(trifluoromethyl)phenoxy]azetidine hydrochloride (1188374-88-0) → 3-(3-(trifluoromethyl)phenoxy)azetidine-1-sulfuryl fluoride

Guidance literature:

With 1-(fluorosulfuryl)-2,3-dimethyl-1H-imidazol-3-ium trifluoromethanesulfonate; triethylamine; In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1002/anie.201712429

upstream raw materials:

tert-butyl 3-(3-(trifluoromethyl)phenoxy)azetidine-1-carboxylate

Downstream raw materials:

5-phenyl-1H-pyrazole-3-carboxylic acid {2-oxo-2-[3-(3-trifluoromethylphenoxy)azetidin-1-yl]ethyl}amide

5-pyridin-3-yl-1H-pyrazole-3-carboxylic acid {2-oxo-2-[3-(3-trifluoromethylphenoxy)azetidin-1-yl]ethyl}amide

Refernces

• 1、 -. "NOVEL PIPERAZINE DERIVATIVES AS INHIBITORS OF STEAROYL-CoA DESATURASE". Page/Page column 87. . Retrieved 2009/10/01.