Pyridazine N-oxide

Base Information

• Chemical Name: Pyridazine N-oxide
• CAS No.: 1457-42-7
• Molecular Formula: C4H4 N2 O
• Molecular Weight: 96.0886
• Hs Code.: 2933990090
• Mol file: 1457-42-7.mol

Synonyms:NSC 343739;Pyridazine N-oxide;Pyridazine oxide;

Chemical Property of Pyridazine N-oxide

Chemical Property:

• Vapor Pressure: 0.275mmHg at 25°C
• Melting Point: 298-305 ºC
• Refractive Index: 1.564
• Boiling Point: 210.7°Cat760mmHg
• Flash Point: 81.2°C
• PSA: 38.35000
• Density: 1.19g/cm³
• LogP: 0.51010

Purity/Quality:

98%,99%, ^*data from raw suppliers

Pyridazine N-oxide 97% ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: Coupling partner in Pd-catalyzed direct arylation reactions.

Technology Process of Pyridazine N-oxide

There total 6 articles about Pyridazine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

1,2-diazine (289-80-5) → pyridazinyl-N-oxide (1457-42-7)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; for 16h;

DOI:10.1002/anie.200602773

Reference yield: 100.0%

→ pyridazinyl-N-oxide (1457-42-7)

Guidance literature:

Reference yield: 80.0%

1,2-diazine (289-80-5) → pyridazinyl-N-oxide (1457-42-7) + pyridazine-N,N-dioxide (19194-87-7)

Guidance literature:

With acetonitrile complex of hypofluorous acid; In dichloromethane; at 0 ℃;

DOI:10.1021/acs.orglett.7b02310

upstream raw materials:

1,2-diazine

4-(3-cyano-1-triazeno)pyridazine 1-oxide potassium salt

Downstream raw materials:

(E)-but-1-en-3-yn-1-ylbenzene

((E)-1-(but-1-en-3-yn-1-yl)-4-methoxybenzene)

(E)-1-(m-Chlorphenyl)but-1-en-3-in

(E)-1-(but-1-en-3-yn-1-yl)-2-methoxybenzene

Refernces

• 1、 Wamsler, Torben,Nielsen, Joergen Tormod,Pedersen, Erik Jonas,Schaumburg, Kjeld. "NMR Studies of Pyridazine-N-Oxide. Determination of Spectroscopic Parameters from the - and Parent Species". . p. 387 - 398. Retrieved 1981.
• 2、 Schie?l, Jasmin,Stein, Philipp M.,Stirn, Judith,Emler, Kirsten,Rudolph, Matthias,Rominger, Frank,Hashmi, A. Stephen K.. "Strategic Approach on N-Oxides in Gold Catalysis – A Case Study". supporting information. p. 725 - 738. Retrieved 2018/10/20.
• 3、 Ma, Xiaoshen,Dang, Hester,Rose, John A.,Rablen, Paul,Herzon, Seth B.. "Hydroheteroarylation of Unactivated Alkenes Using N-Methoxyheteroarenium Salts". supporting information. p. 5998 - 6007. Retrieved 2017/05/04.