MOZ-IN-3

Base Information

Chemical Name:MOZ-IN-3
CAS No.:2055397-18-5
Molecular Formula:C₂₀H₁₇FN₂O₃S
Molecular Weight:384.431
Hs Code.:
Mol file:2055397-18-5.mol

Synonyms:

Suppliers and Price of MOZ-IN-3

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
MOZ-IN-3
25mg
$ 1100.00

DC Chemicals
WM-8014 >98%
250 mg
$ 980.00

DC Chemicals
WM-8014 >98%
1g
$ 1900.00

ChemScene
WM-8014 99.64%
100mg
$ 2850.00

ChemScene
WM-8014 99.64%
50mg
$ 1850.00

ChemScene
WM-8014 99.64%
25mg
$ 1100.00

ChemScene
WM-8014 99.64%
10mg
$ 550.00

ChemScene
WM-8014 99.64%
5mg
$ 350.00

Cayman Chemical
MOZ-IN-3
5mg
$ 145.00

Cayman Chemical
MOZ-IN-3
1mg
$ 52.00

Total 12 raw suppliers

Chemical Property of MOZ-IN-3

Chemical Property:

PKA:7.15±0.25(Predicted)
Density:1.307±0.06 g/cm3(Predicted)

Purity/Quality:

99%, ^*data from raw suppliers

MOZ-IN-3 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Description MOZ-IN-3 is an inhibitor of lysine acetyltransferase 6A (KAT6A/MOZ) and KAT6B/MORF (IC50s = 8 and 28 nM, respectively). It is selective for KAT6A and KAT6B over KAT5 and KAT7 (IC50s = 224 and 342 nM, respectively). MOZ-IN-3 induces cell cycle arrest in and inhibits proliferation of mouse embryonic fibroblasts (IC50 = 2.4 μM) and inhibits proliferation of EMRK1184 lymphoma cells (IC50 = 2.3 μM). It induces genetic and morphological changes associated with cellular senescence without inducing DNA damage, apoptosis, or necrosis. MOZ-IN-3 (10 μM) decreases global levels of acetylated histone H3 lysine 14 (H3K14Ac) by 49% and reduces H3K9Ac levels at the transcription start sites of Ezh2, Melk, and E2f2.
Uses MOZ-IN-3 is a highly potent and selective inhibitor of lysine acetyltransferases, KAT6A and KAT6B.

Technology Process of MOZ-IN-3

There total 6 articles about MOZ-IN-3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 4-fluoro-5-methyl-[1,1’-biphenyl]-3-carboxylic acid

: 80-17-1
benzenesufonyl hydrazide

: 2055397-18-5
N'-(4-fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide

Guidance literature:: 4-fluoro-5-methyl-[1,1’-biphenyl]-3-carboxylic acid; With dicyclohexyl-carbodiimide; In tetrahydrofuran; at 20 ℃; for 0.0833333h; Inert atmosphere;

benzenesufonyl hydrazide; In tetrahydrofuran; at 65 ℃; for 24h; Inert atmosphere;
DOI:10.1021/acs.jmedchem.9b00665

Reference yield: 35.0%

: 2055397-18-5
N'-(4-fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide

Guidance literature:: With 1-hydroxy-7-aza-benzotriazole; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In acetonitrile; at 40 ℃; for 17h; Inert atmosphere;

Reference yield:

: 98-80-6
phenylboronic acid

: 2055397-18-5
N'-(4-fluoro-5-methyl-[1,1'-biphenyl]-3-carbonyl)benzenesulfonohydrazide

Guidance literature:: Multi-step reaction with 3 steps

1.1: bis-triphenylphosphine-palladium(II) chloride; potassium carbonate / water; tetrahydrofuran / Reflux

2.1: n-butyllithium; potassium tert-butylate / tetrahydrofuran; hexane / 2 h / -78 °C

2.2: -78 °C

3.1: dicyclohexyl-carbodiimide / tetrahydrofuran / 0.08 h / 20 °C / Inert atmosphere

3.2: 24 h / 65 °C / Inert atmosphere

With bis-triphenylphosphine-palladium(II) chloride; n-butyllithium; potassium tert-butylate; potassium carbonate; dicyclohexyl-carbodiimide; In tetrahydrofuran; hexane; water; 1.1: |Suzuki Coupling;
DOI:10.1021/acs.jmedchem.9b00665