5-Chloro-2-methylthiazolo[5,4-b]pyridine

Base Information

• Chemical Name: 5-Chloro-2-methylthiazolo[5,4-b]pyridine
• CAS No.: 109202-21-3
• Molecular Formula: C₇H₅ClN₂S
• Molecular Weight: 184.649
• Hs Code.: 2934999090
• DSSTox Substance ID: DTXSID50547793
• Wikidata: Q82426253
• Mol file: 109202-21-3.mol

Synonyms:5-chloro-2-methylthiazolo[5,4-b]pyridine;109202-21-3;5-CHLORO-2-METHYL-[1,3]THIAZOLO[5,4-B]PYRIDINE;5-Chloro-2-methyl-thiazolo[5,4-b]pyridine;Thiazolo[5,4-b]pyridine, 5-chloro-2-methyl-;SCHEMBL1661549;DTXSID50547793;QZKHWZUBIKKZEY-UHFFFAOYSA-N;AMY17141;MFCD18256933;BS-53075;E78332;5-Chloro-2-methyl[1,3]thiazolo[5,4-b]pyridine;A937475

Chemical Property of 5-Chloro-2-methylthiazolo[5,4-b]pyridine

Chemical Property:

• PSA: 54.02000
• LogP: 2.65310
• XLogP3: 3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 0
• Exact Mass: 183.9861970
• Heavy Atom Count: 11
• Complexity: 155

Purity/Quality:

100% ^*data from raw suppliers

5-Chloro-2-methylthiazolo[5,4-b]pyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=C(S1)N=C(C=C2)Cl

Technology Process of 5-Chloro-2-methylthiazolo[5,4-b]pyridine

There total 3 articles about 5-Chloro-2-methylthiazolo[5,4-b]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ 5-chloro-2-methyl-thiazolo[5,4-b]pyridine (109202-21-3)

Guidance literature:

With potassium hydroxide; potassium hexacyanoferrate(III);

Reference yield:

thioacetic acid S-(3-acetylamino-6-chloro-[2]pyridyl ester) → 5-chloro-2-methyl-thiazolo[5,4-b]pyridine (109202-21-3)

Guidance literature:

With acetic anhydride; acetic acid; zinc;

Reference yield:

3-amino-2,6-dichloropyridine (62476-56-6) + O-Ethyl thioacetate (926-67-0) → 5-chloro-2-methyl-thiazolo[5,4-b]pyridine (109202-21-3)

Guidance literature:

With ethylmagnesium bromide; Yield given. Multistep reaction; 1) THF, reflux; 2) reflux 1 h, then room temp., 2 h;

upstream raw materials:

3-amino-2,6-dichloropyridine

O-Ethyl thioacetate

Downstream raw materials:

(chloro-2 nitro-5 styryl)-2 chloro-7 thiazolo<5,4-b>pyridine