N-methyl-6-(trifluoromethyl)pyridin-3-amine

Base Information

• Chemical Name: N-methyl-6-(trifluoromethyl)pyridin-3-amine
• CAS No.: 1428241-50-2
• Molecular Formula: C₇H₇F₃N₂
• Molecular Weight: 176.141
• Mol file: 1428241-50-2.mol

Synonyms:

Chemical Property of N-methyl-6-(trifluoromethyl)pyridin-3-amine

Chemical Property:

Purity/Quality:

95%-98% ^*data from raw suppliers

Methyl-(6-trifluoromethylpyridin-3-yl)-amine 95%+ ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-methyl-6-(trifluoromethyl)pyridin-3-amine

There total 3 articles about N-methyl-6-(trifluoromethyl)pyridin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

N-[6-(trifluoromethyl)pyridin-3-yl]formamide → N-methyl-6-(trifluoromethyl)pyridin-3-amine (1428241-50-2)

Guidance literature:

With dimethylsulfide borane complex; In tetrahydrofuran; at 0 - 65 ℃; for 4h; Inert atmosphere;

DOI:10.1021/acsmedchemlett.0c00649

Reference yield:

6-(trifluoromethyl)pyridin-3-amine (106877-33-2) → N-methyl-6-(trifluoromethyl)pyridin-3-amine (1428241-50-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: acetic anhydride / 2 h / 50 °C

1.2: 23 h / 20 °C / Inert atmosphere

2.1: dimethylsulfide borane complex / tetrahydrofuran / 4 h / 0 - 65 °C / Inert atmosphere

With dimethylsulfide borane complex; acetic anhydride; In tetrahydrofuran;

DOI:10.1021/acsmedchemlett.0c00649

Reference yield:

→ N-methyl-6-(trifluoromethyl)pyridin-3-amine (1428241-50-2)

Guidance literature:

With sodium hydride; In tetrahydrofuran; mineral oil; at 20 ℃; for 3h;

In tetrahydrofuran; mineral oil; at 40 ℃; for 9h;

upstream raw materials:

6-(trifluoromethyl)pyridin-3-amine

Downstream raw materials:

C₁₈H₁₆F₃N₅O₂

C₂₁H₁₈F₃N₃O₃

C₂₀H₁₈F₃N₃O₃

C₁₉H₁₆F₃N₃O₃