4-(2-tert-Butoxy-2-oxoethyl)phenylalanine

Base Information

Chemical Name:4-(2-tert-Butoxy-2-oxoethyl)phenylalanine
CAS No.:222842-90-2
Molecular Formula:C15H21NO4
Molecular Weight:279.336
Hs Code.:
DSSTox Substance ID:DTXSID00697570
Mol file:222842-90-2.mol

Synonyms:H-L-Phe(4-CH2COOtBu)-OH;222842-90-2;DTXSID00697570;4-(2-tert-Butoxy-2-oxoethyl)phenylalanine

Suppliers and Price of 4-(2-tert-Butoxy-2-oxoethyl)phenylalanine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 1 raw suppliers

Chemical Property of 4-(2-tert-Butoxy-2-oxoethyl)phenylalanine

Chemical Property:

XLogP3:-0.6
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:7
Exact Mass:279.14705815
Heavy Atom Count:20
Complexity:340

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)(C)OC(=O)CC1=CC=C(C=C1)CC(C(=O)O)N

Technology Process of 4-(2-tert-Butoxy-2-oxoethyl)phenylalanine

There total 3 articles about 4-(2-tert-Butoxy-2-oxoethyl)phenylalanine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 222843-51-8
benzyl (2R,3S)-3-<4-(tert-butoxycarbonylmethyl)phenyl>-2-oxo-5,6-diphenyl-morpholine-4-carboxylate

: 222842-90-2
4-(tert-butoxycarbonylmethyl)-L-phenylalanine

Guidance literature:: With hydrogen; palladium; In tetrahydrofuran; methanol; for 20h; Ambient temperature;
DOI:10.1016/S0040-4020(99)00076-9

Reference yield:

: 33155-60-1
t-butyl p-tolylacetate

: 222842-90-2
4-(tert-butoxycarbonylmethyl)-L-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: NBS, (PhCOO)2O / CCl₄

2: 42 percent / LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 30 min, 2.) -78 deg C, 2 h; room temperature, 1 h

3: 95 percent / H₂ / Pd black / tetrahydrofuran; methanol / 20 h / Ambient temperature

With N-Bromosuccinimide; (PhCOO)2O; hydrogen; lithium hexamethyldisilazane; palladium; In tetrahydrofuran; methanol; tetrachloromethane; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4020(99)00076-9

Reference yield:

: 77292-91-2
α-(4-bromomethylphenyl)acetic acid tert-butyl ester

: 222842-90-2
4-(tert-butoxycarbonylmethyl)-L-phenylalanine

Guidance literature:: Multi-step reaction with 2 steps

1: 42 percent / LiHMDS / tetrahydrofuran; hexamethylphosphoric acid triamide / 1.) -78 deg C, 30 min, 2.) -78 deg C, 2 h; room temperature, 1 h

2: 95 percent / H₂ / Pd black / tetrahydrofuran; methanol / 20 h / Ambient temperature

With hydrogen; lithium hexamethyldisilazane; palladium; In tetrahydrofuran; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide;
DOI:10.1016/S0040-4020(99)00076-9