C₁₈H₂₁FN₄O

Base Information

Chemical Name:C₁₈H₂₁FN₄O
CAS No.:1580494-69-4
Molecular Formula:C₁₈H₂₁FN₄O
Molecular Weight:328.389
Hs Code.:

C<sub>18</sub>H<sub>21</sub>FN<sub>4</sub>O

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of C₁₈H₂₁FN₄O

Chemical Property:

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Technology Process of C₁₈H₂₁FN₄O

There total 4 articles about C₁₈H₂₁FN₄O which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61266-36-2
methyl 4-(3-hydroxypropynyl)benzoate

: 1580494-69-4
C₁₈H₂₁FN₄O

Guidance literature:: Multi-step reaction with 4 steps

1.1: (bis-(2-methoxyethyl)amino)sulfur trufluoride / dichloromethane / 48 h / 20 °C

2.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C

2.2: 2 h / -60 °C

3.1: sodium hydroxide / ethanol / 0.25 h

3.2: 96 h / 20 °C

4.1: hydrazine hydrate; acetic acid / ethanol / 5 h / 80 °C

With n-butyllithium; hydrazine hydrate; acetic acid; sodium hydroxide; (bis-(2-methoxyethyl)amino)sulfur trufluoride; In tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1016/j.bmcl.2014.01.080

Reference yield:

: 1580494-61-6
methyl 4-(3-fluoroprop-1-yn-1-yl)benzoate

: 1580494-69-4
C₁₈H₂₁FN₄O

Guidance literature:: Multi-step reaction with 3 steps

1.1: n-butyllithium / tetrahydrofuran / 0.5 h / -60 °C

1.2: 2 h / -60 °C

2.1: sodium hydroxide / ethanol / 0.25 h

2.2: 96 h / 20 °C

3.1: hydrazine hydrate; acetic acid / ethanol / 5 h / 80 °C

With n-butyllithium; hydrazine hydrate; acetic acid; sodium hydroxide; In tetrahydrofuran; ethanol;
DOI:10.1016/j.bmcl.2014.01.080

Reference yield:

: 1580494-63-8
C₁₂H₈FNO

: 1580494-69-4
C₁₈H₂₁FN₄O

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydroxide / ethanol / 0.25 h

1.2: 96 h / 20 °C

2.1: hydrazine hydrate; acetic acid / ethanol / 5 h / 80 °C

With hydrazine hydrate; acetic acid; sodium hydroxide; In ethanol;
DOI:10.1016/j.bmcl.2014.01.080