CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

Base Information

• Chemical Name: CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)
• CAS No.: 144750-42-5
• Molecular Formula: C15H14ClNO2S.ClH
• Molecular Weight: 344.262
• Hs Code.: 2934999090
• Mol file: 144750-42-5.mol

Synonyms:[(+)-(S)-(o-chlorophenyl)-6,7-dihydrothieno[3,2-c]pyridine-5(4H)-acetic acid hydrochloride;Clopidogrel Acid Hydrochloride;

Chemical Property of CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

Chemical Property:

• PSA: 68.78000
• LogP: 4.32540
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

98%min, ^*data from raw suppliers

Clopidogrel Carboxylic Acid Hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: Clopidogrel Carboxylic Acid Hydrochloride (Clopidogrel EP Impurity A; Clopidogrel Impurity A; Clopidogrel USP A) is the hydrochloride salt of a metabolite of the drug Clopidogrel.

Technology Process of CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE)

There total 4 articles about CLOPIDOGREL RELATED COMPOUND A (20 MG) ((S)-(O-CHLOROPHENYL)-6,7-DIHYDROTHIENO[3,2-C]PYRI-DINE-5(4H)-ACETIC ACID, HYDROCHLORIDE) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

SR 26334 (144457-28-3) → (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride (144750-42-5)

Guidance literature:

With hydrogenchloride; In methanol; water; acetone; at 5 - 40 ℃; for 4h;

Reference yield:

(S)-(+)-clopidogrel (113665-84-2,94188-84-8) → (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride (144750-42-5)

Guidance literature:

With hydrogenchloride; In pentan-3-one; at -10 - 10 ℃; for 0.5h; Product distribution / selectivity;

Reference yield:

(S)-(+)-clopidogrel (113665-84-2,94188-84-8) → methyl (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetate bisulfate (120202-71-3,144077-07-6) + (S)-(+)-2-(2-chlorophenyl)-2-(6,7-dihydrothieno-[3,2-c]pyridin-5(4H)-yl)acetic acid hydrochloride (144750-42-5)

Guidance literature:

With sulfuric acid;

DOI:10.1080/00397911.2011.635393

upstream raw materials:

(S)-(+)-clopidogrel

SR 26334

Downstream raw materials:

(S)-(+)-clopidogrel

C₁₅H₁₃Cl₂NOS

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