AC 010220 (dihydrochloride)

Base Information

Chemical Name:AC 010220 (dihydrochloride)
CAS No.:1132827-21-4
Molecular Formula:C₂₉H₃₂N₆O₄S*ClH
Molecular Weight:597.138
Hs Code.:
Mol file:1132827-21-4.mol

Synonyms:UNII-WK7Q6ZIZ10;Quizartinib dihydrochloride;

Suppliers and Price of AC 010220 (dihydrochloride)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

DC Chemicals
Quizartinibhydrochloride >98%
100 mg
$ 198.00

DC Chemicals
Quizartinibhydrochloride >98%
50 mg
$ 118.00

DC Chemicals
Quizartinibhydrochloride >98%
10 mg
$ 68.00

Biorbyt Ltd
Quizartinib hydrochloride
100 mg
$ 411.40

Biorbyt Ltd
Quizartinib hydrochloride
50 mg
$ 321.30

Biorbyt Ltd
Quizartinib hydrochloride
10 mg
$ 200.60

American Custom Chemicals Corporation
AC-220 DIHYDROCHLORIDE 95.00%
5MG
$ 497.61

Total 12 raw suppliers

Chemical Property of AC 010220 (dihydrochloride)

Chemical Property:

PSA：137.63000
LogP:6.89330

Purity/Quality:

99% ,99.9%, ^*data from raw suppliers

Quizartinibhydrochloride >98% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of AC 010220 (dihydrochloride)

There total 7 articles about AC 010220 (dihydrochloride) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 950769-58-1
quizartinib

: 1132827-21-4,950769-62-7
N-(5-tert-butyl-isoxazol-3-yl)-N'-{4-[7-(2-morpholin-4-yl-ethoxy)imidazo[2,1-b][1,3]benzothiazol-2-yl]phenyl}urea hydrochloride

Guidance literature:: With hydrogenchloride; In methanol; methylene chlloride;

Reference yield: 98.0%

: 950769-58-1
quizartinib

: 1132827-21-4,950769-62-7
Quizartinib dihydrochloride

Guidance literature:: With hydrogenchloride; In methanol; diethyl ether; dichloromethane; Product distribution / selectivity;

Reference yield:

: 26278-79-5
2-amino-6-hydroxybenzothiazole

: 1132827-21-4,950769-62-7
Quizartinib dihydrochloride

Guidance literature:: Multi-step reaction with 5 steps

1: sodium hydrogencarbonate / butan-1-ol / 110 - 115 °C / Industry scale

2: potassium carbonate; tetra-(n-butyl)ammonium iodide / N,N-dimethyl-formamide / 5 h / 90 - 95 °C / Industry scale

3: hydrogen / Raney nickel / tetrahydrofuran; methanol / 24 h / 7757.43 Torr / autoclave; Inert atmosphere

4: dmap; triethylamine / tetrahydrofuran / 18 h / 60 °C

5: hydrogenchloride / water; methanol / 1 h / Reflux

With hydrogenchloride; dmap; hydrogen; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; potassium carbonate; triethylamine; Raney nickel; In tetrahydrofuran; methanol; water; N,N-dimethyl-formamide; butan-1-ol;