1-[(2S,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

Base Information

Chemical Name:1-[(2S,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione
CAS No.:84414-90-4
Molecular Formula:C10H12N2O4
Molecular Weight:224.216
Hs Code.:
UNII:J69N0KNC59
Nikkaji Number:J371.832H
Mol file:84414-90-4.mol

Synonyms:84414-90-4;Stavudinealpha-anomer;J69N0KNC59;Stavudine impurity E [WHO-IP];UNII-J69N0KNC59;1-[(2S,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione;1-((2S,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione [WHO-IP];2,4(1H,3H)-Pyrimidinedione, 1-(2,5-dihydro-5-(hydroxymethyl)-2-furanyl)-5-methyl-, (2S-trans)-;STAVUDINE.ALPHA.-ANOMER;1-((2S,5S)-5-(Hydroxymethyl)-2,5-dihydrofuran-2-yl)-5-methylpyrimidine-2,4(1H,3H)-dione

Suppliers and Price of 1-[(2S,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
α-Stavudine
100mg
$ 1760.00

AvaChem
Alpha-Stavudine
25mg
$ 425.00

AvaChem
Alpha-Stavudine
10mg
$ 225.00

AvaChem
Alpha-Stavudine
5mg
$ 125.00

Total 18 raw suppliers

Chemical Property of 1-[(2S,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

Chemical Property:

PSA：84.32000
Density:1.374±0.06 g/cm3 (20 ºC 760 Torr)
LogP:-0.70910
XLogP3:-0.8
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:2
Exact Mass:224.07970687
Heavy Atom Count:16
Complexity:388

Purity/Quality:

98%Min ^*data from raw suppliers

α-Stavudine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CN(C(=O)NC1=O)C2C=CC(O2)CO
Isomeric SMILES:CC1=CN(C(=O)NC1=O)[C@@H]2C=C[C@H](O2)CO
Uses α-Stavudine is an epimer of Stavudine (S685250), an antiviral used to prevent and treat HIV/AIDS.

Technology Process of 1-[(2S,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione

There total 24 articles about 1-[(2S,5S)-5-(hydroxymethyl)-2,5-dihydrofuran-2-yl]-5-methylpyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

: 139212-94-5,139212-95-6
1-(5-O-tert-butyldiphenylsilyl-2-deoxy-3-O-methylsulfonyl-α,β-D-erythro-pentofuranosyl)thymine

: 1-(3,5-anhydro-2-deoxy-α-D-threo-pentofuranosyl)thymine

: 3056-17-5,26638-87-9,84414-90-4,133008-05-6,135212-56-5
1-(2,3-dideoxy-D-glycero-pent-2-enofuranosyl)thymine

: 16053-52-4,28854-96-8,3545-96-8,50-88-4
threothymidine

Guidance literature:: With sodium methylate; In methanol; for 24h; Heating;
DOI:10.3891/acta.chem.scand.45-1060

Reference yield: 27.0%

: 139212-87-6,139212-88-7
1-(5-O-tert-butyldiphenylsilyl-2,3-dideoxy-3-iodo-D-threo-pentafuranosyl)thymine

: 37782-89-1
1-(5-hydroxymethyl-2,3-dihydrofuran-2-yl)thymine

: 3056-17-5,26638-87-9,84414-90-4,133008-05-6,135212-56-5
1-(2,3-dideoxy-D-glycero-pent-2-enofuranosyl)thymine

Guidance literature:: With sodium methylate; In methanol; for 8h; Heating;
DOI:10.3891/acta.chem.scand.45-1060

Reference yield:

: 5-Methyl-1-((S)-5-trityloxymethyl-2,5-dihydro-furan-2-yl)-1H-pyrimidine-2,4-dione

: 84414-90-4
1-(2,3-dideoxy-α-D-glycero-pent-2-enofuranosyl)thymine

: 3056-17-5
stavudin

Guidance literature:: With Dowex ^R 50W; hydrogen cation; In methanol; Yield given. Yields of byproduct given;
DOI:10.1016/0040-4039(96)01293-2