N-(3,4-DICHLOROPHENYL)MALEAMIC ACID

Base Information

• Chemical Name: N-(3,4-DICHLOROPHENYL)MALEAMIC ACID
• CAS No.: 54012-56-5
• Molecular Formula: C₁₀H₇Cl₂NO₃
• Molecular Weight: 260.076
• Hs Code.: 2924299090
• Mol file: 54012-56-5.mol

Synonyms:NSC 237627

Chemical Property of N-(3,4-DICHLOROPHENYL)MALEAMIC ACID

Chemical Property:

• Vapor Pressure: 2.44E-10mmHg at 25°C
• Melting Point: 205°C
• Boiling Point: 488.1°Cat760mmHg
• Flash Point: 249°C
• PSA: 66.40000
• Density: 1.551g/cm³
• LogP: 2.64570

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(3,4-DICHLOROPHENYL)MALEAMIC ACID

There total 1 articles about N-(3,4-DICHLOROPHENYL)MALEAMIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

maleic anhydride (108-31-6) + m,p-dichloroaniline (95-76-1) → C10H7Cl2NO3 (54012-56-5)

Guidance literature:

In diethyl ether; at 20 ℃; for 2h;

DOI:10.1021/jm301565b

Reference yield:

C10H7Cl2NO3 (54012-56-5) → 1-(3,4-dichlorophenyl)pyrrole-2,5-dione (19844-27-0)

Guidance literature:

With sodium acetate; In acetic anhydride; at 20 - 100 ℃; for 0.5h;

DOI:10.1021/jm301565b

Reference yield:

C10H7Cl2NO3 (54012-56-5) → 3-chloro-1-(3,4-dichlorophenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrrole-2,5-dione (370572-36-4)

Guidance literature:

Multi-step reaction with 3 steps

1: sodium acetate / acetic anhydride / 0.5 h / 20 - 100 °C

2: thionyl chloride; pyridine / 1.25 h / 0 °C / Reflux

3: dichloromethane / 2 h / 20 °C

With pyridine; thionyl chloride; sodium acetate; In dichloromethane; acetic anhydride;

DOI:10.1021/jm301565b

upstream raw materials:

maleic anhydride

m,p-dichloroaniline

Downstream raw materials:

1-(3,4-dichlorophenyl)pyrrole-2,5-dione

3-chloro-1-(3,4-dichlorophenyl)-4-(4-methylpiperazin-1-yl)-1H-pyrrole-2,5-dione