(6-AMINOPYRIDIN-3-YL)BORONIC ACID

Base Information

• Chemical Name: (6-AMINOPYRIDIN-3-YL)BORONIC ACID
• CAS No.: 851524-96-4
• Molecular Formula: C5H7BN2O2
• Molecular Weight: 137.934
• Hs Code.: 2933399090
• Mol file: 851524-96-4.mol

Synonyms:6-Aminopyridin-3-yl)boronic acid;6-Aminopyridine-3-boronicacid;

Chemical Property of (6-AMINOPYRIDIN-3-YL)BORONIC ACID

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.586
• Boiling Point: 388.271 °C at 760 mmHg
• PKA: 4.24±0.10(Predicted)
• Flash Point: 188.62 °C
• PSA: 79.37000
• Density: 1.334 g/cm³
• LogP: -1.07520
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

Purity/Quality:

97% ^*data from raw suppliers

2-Aminopyridine-5-boronicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (6-AMINOPYRIDIN-3-YL)BORONIC ACID

There total 1 articles about (6-AMINOPYRIDIN-3-YL)BORONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

→ 2-amino-5-pyridinyl boronic acid (851524-96-4)

Guidance literature:

With sodium hydroxide; In water; at 0 - 5 ℃; pH=7.2;

Reference yield: 99.0%

2-amino-5-pyridinyl boronic acid (851524-96-4) + (Z)-2-(4-bromobenzylidene)benzofuran-3(2H)-one (81281-79-0,83406-07-9,81281-78-9) → (Z)-2-(4-(6-aminopyridin-3-yl)benzylidene)benzofuran-3(2H)-one (1613189-88-0)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.04.076

Reference yield: 98.0%

2-amino-5-pyridinyl boronic acid (851524-96-4) + (Z)-2-benzylidene-3-oxo-2,3-dihydrobenzofuran-6-yl trifluoromethanesulfonate (1613190-18-3) → (Z)-6-(6-aminopyridin-3-yl)-2-benzylidenebenzofuran-3(2H)-one (1613190-12-7)

Guidance literature:

With bis-triphenylphosphine-palladium(II) chloride; sodium carbonate; In 1,4-dioxane; at 100 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.ejmech.2014.04.076

Downstream raw materials:

(R)-6-allyl-3-((S)-1-(4-(6-aminopyridin-3-yl)phenyl)ethyl)-6-phenyl-1,3-oxazinan-2-one

C₂₃H₂₄N₆O₂

(R)-6-allyl-3-((S)-1-(4-(6-aminopyridin-3-yl)phenyl)ethyl)-6-(4-fluorophenyl)-1,3-oxazinan-2-one

(R)-3-((S)-1-(4-(6-aminopyridin-3-yl)phenyl)ethyl)-6-(4-fluorophenyl)-6-(3-hydroxypropyl)-1,3-oxazinan-2-one