Manidipine

Base Information

• Chemical Name: Manidipine
• CAS No.: 120092-68-4
• Molecular Formula: C35H38N4O6
• Molecular Weight: 610.70
• Mol file: 120092-68-4.mol

Synonyms:2-(4-(Diphenylmethyl)-1-piperazinyl)-ethyl methyl (-)-2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate;Manidipine 6300;UNII-6O4754US88;

Chemical Property of Manidipine

Chemical Property:

• Vapor Pressure: 1.07E-20mmHg at 25°C
• Melting Point: 125-128oC
• Refractive Index: 1.6
• Boiling Point: 721.996 °C at 760 mmHg
• Flash Point: 390.449 °C
• PSA: 116.93000
• Density: 1.232 g/cm³
• LogP: 5.68080
• Storage Temp.: -20°C Freezer
• Solubility.: DMSO (Slightly), Methanol (Slightly, Sonicated)

Purity/Quality:

98%,99%, ^*data from raw suppliers

MANIDIPINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (S)-Manidipine enantiomer. A dihydropyridine calcium channel blocker. Antihypertensive

Technology Process of Manidipine

There total 18 articles about Manidipine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

Manidipine dihydrochloride (89226-75-5,119992-99-3,126229-12-7,126372-04-1) → manidipine (89226-50-6,120092-68-4,133082-19-6)

Guidance literature:

With sodium hydroxide; In water; Cooling with ice;

Reference yield: 91.43%

β-aminocrotonic acid 1-diphenylmethyl-4-piperazine ester + methyl 2-(3-nitrophenylmethylene)acetoacetate (39562-17-9) → manidipine (89226-50-6,120092-68-4,133082-19-6)

Guidance literature:

In ethanol; at 40 - 75 ℃; for 6.5h; Temperature;

Reference yield: 81.0%

manidipine (89226-50-6,120092-68-4,133082-19-6) → (S)-Manidipine (126451-47-6,120092-68-4,133082-19-6)

Guidance literature:

With O,O′-di-p-anisoyl-D-tartaric acid; In hexane; ethyl acetate; for 2h; Reagent/catalyst; Solvent;

upstream raw materials:

3-nitro-benzaldehyde

2-(4-diphenylmethyl-1-piperazinyl)ethyl acetoacetate

methyl 3-aminocrotonate

2-(4-diphenylmethyl-1-piperazinyl)ethyl 2-(3-nitrobenzylidene)acetoacetate

Downstream raw materials:

(S)-Manidipine

Refernces

• 1、 -. "Preparation method of (S)-manidipine". Paragraph 0040; 0041; 0042. . Retrieved 2016/10/20.
• 2、 -. "POLYMORPHIC FORMS OF MANIDIPINE". . . Retrieved 2011/04/14.