8-hydroxyethanamine-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene

Base Information

• Chemical Name: 8-hydroxyethanamine-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene
• CAS No.: 1378342-74-5
• Molecular Formula: C₃₄H₂₄BBr₂F₂N₃O
• Molecular Weight: 699.2
• Mol file: 1378342-74-5.mol

Synonyms:

Chemical Property of 8-hydroxyethanamine-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 8-hydroxyethanamine-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene

There total 7 articles about 8-hydroxyethanamine-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.9%

8-chloromethyl-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene (1378342-76-7) → 8-hydroxyethanamine-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene (1378342-74-5)

Guidance literature:

With sodium methoxide; hydroxylamine hydrochloride; In methanol; for 24h; Reflux; Inert atmosphere;

DOI:10.1039/c2cc31426f

Reference yield:

1-azidostyrene (16717-64-9) → 8-hydroxyethanamine-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene (1378342-74-5)

Guidance literature:

Multi-step reaction with 5 steps

1: toluene / 4 h / Reflux

2: sodium hydride / dimethyl sulfoxide / 6 h / 20 °C

3: dichloromethane / 4 h / 50 °C / Inert atmosphere

4: boron trifluoride diethyl etherate; triethylamine / dichloromethane; toluene / 20 - 50 °C / Inert atmosphere

5: sodium methoxide; hydroxylamine hydrochloride / methanol / 24 h / Reflux; Inert atmosphere

With sodium methoxide; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium hydride; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide; toluene;

DOI:10.1039/c2cc31426f

Reference yield:

1-(1-azido-2-bromoethyl)benzene (29847-04-9) → 8-hydroxyethanamine-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene (1378342-74-5)

Guidance literature:

Multi-step reaction with 6 steps

1: sodium hydroxide / water; dimethyl sulfoxide / 0.4 h / 25 °C / Inert atmosphere

2: toluene / 4 h / Reflux

3: sodium hydride / dimethyl sulfoxide / 6 h / 20 °C

4: dichloromethane / 4 h / 50 °C / Inert atmosphere

5: boron trifluoride diethyl etherate; triethylamine / dichloromethane; toluene / 20 - 50 °C / Inert atmosphere

6: sodium methoxide; hydroxylamine hydrochloride / methanol / 24 h / Reflux; Inert atmosphere

With sodium methoxide; boron trifluoride diethyl etherate; hydroxylamine hydrochloride; sodium hydride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; dimethyl sulfoxide; toluene;

DOI:10.1039/c2cc31426f

upstream raw materials:

1-azidostyrene

2-(4-bromophenyl)-4-phenyl-1H-pyrrole

C₃₄H₂₃Br₂ClN₂

8-chloromethyl-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene

Downstream raw materials:

8-methyl-4,4-difluoro-1,7-diphenyl-3,5-di(1-bromophenyl)-4-bora-3a,4a-diaza-s-indacene