Technology Process of methyl 2-(2-chloro-5-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)acetate
There total 9 articles about methyl 2-(2-chloro-5-methyl-4-(5-methyl-1,2,4-oxadiazol-3-yl)phenyl)acetate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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for 16h;
Reflux;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: nitric acid; sulfuric acid / water / 3 h / 0 °C / Cooling with ice
2.1: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 16 h / 90 °C
3.1: ruthenium(III) chloride trihydrate; tetra-(n-butyl)ammonium iodide / ethyl acetate / 0 °C
3.2: 2 h / 20 °C
4.1: thionyl chloride / 4.25 h / 100 °C
5.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / water; methanol / 0.67 h / 0 - 20 °C
6.1: copper(ll) bromide; tert.-butylnitrite; toluene-4-sulfonic acid; tetrabutylammomium bromide / acetonitrile / 4 h / 20 °C
7.1: zinc; tris-(dibenzylideneacetone)dipalladium(0); (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere
8.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 4 h / 70 °C
9.1: 16 h / Reflux
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); thionyl chloride; tert.-butylnitrite; nickel(II) chloride hexahydrate; ruthenium(III) chloride trihydrate; sulfuric acid; hydroxylamine hydrochloride; tetrabutylammomium bromide; nitric acid; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; toluene-4-sulfonic acid; copper(ll) bromide; zinc;
In
1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: tetrakis(triphenylphosphine) palladium(0) / 1,4-dioxane / 16 h / 90 °C
2.1: ruthenium(III) chloride trihydrate; tetra-(n-butyl)ammonium iodide / ethyl acetate / 0 °C
2.2: 2 h / 20 °C
3.1: thionyl chloride / 4.25 h / 100 °C
4.1: nickel(II) chloride hexahydrate; sodium tetrahydroborate / water; methanol / 0.67 h / 0 - 20 °C
5.1: copper(ll) bromide; tert.-butylnitrite; toluene-4-sulfonic acid; tetrabutylammomium bromide / acetonitrile / 4 h / 20 °C
6.1: zinc; tris-(dibenzylideneacetone)dipalladium(0); (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 1.5 h / 120 °C / Inert atmosphere
7.1: hydroxylamine hydrochloride; sodium hydrogencarbonate / methanol / 4 h / 70 °C
8.1: 16 h / Reflux
With
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; sodium tetrahydroborate; tris-(dibenzylideneacetone)dipalladium(0); tetrakis(triphenylphosphine) palladium(0); thionyl chloride; tert.-butylnitrite; nickel(II) chloride hexahydrate; ruthenium(III) chloride trihydrate; hydroxylamine hydrochloride; tetrabutylammomium bromide; tetra-(n-butyl)ammonium iodide; sodium hydrogencarbonate; toluene-4-sulfonic acid; copper(ll) bromide; zinc;
In
1,4-dioxane; methanol; water; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;