(R)-2-phenyl-1-((R)-pyrrolidin-2-yl)ethanol

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Chemical Name:(R)-2-phenyl-1-((R)-pyrrolidin-2-yl)ethanol
CAS No.:1399282-38-2
Molecular Formula:C₁₂H₁₇NO
Molecular Weight:191.273
Hs Code.:

Synonyms:

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Chemical Property of (R)-2-phenyl-1-((R)-pyrrolidin-2-yl)ethanol

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Technology Process of (R)-2-phenyl-1-((R)-pyrrolidin-2-yl)ethanol

There total 7 articles about (R)-2-phenyl-1-((R)-pyrrolidin-2-yl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1399282-23-5
(R)-N,N-dibenzyl-1-((S)-2,2-dimethyl-1,3-doxolan-4-yl)-3-(trimethylsilyl)prop-2-yn-1-amine

: 1399282-38-2
(R)-2-phenyl-1-((R)-pyrrolidin-2-yl)ethanol

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 1 h / 0 °C / Inert atmosphere

2.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

2.2: 2 h / -78 - 20 °C / Inert atmosphere

3.1: Pd(OH)2/C; hydrogen / ethanol / 24 h / 20 °C / 5171.62 Torr / Inert atmosphere

4.1: sodium ethanolate / ethanol / 2 h / Inert atmosphere; Reflux

5.1: hydrogenchloride / ethanol / 2 h / 20 °C / Inert atmosphere

6.1: triphenylphosphine; di-isopropyl azodicarboxylate / chloroform / 36 h / Inert atmosphere; Reflux

7.1: copper(l) iodide / tetrahydrofuran; diethyl ether; pentane / 2 h / -35 °C / Inert atmosphere

8.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 0 °C / Inert atmosphere; Reflux

With hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; Pd(OH)2/C; tetrabutyl ammonium fluoride; hydrogen; sodium ethanolate; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; hexane; chloroform; pentane; 6.1: |Mitsunobu Displacement;
DOI:10.1039/c2ob26007g

Reference yield:

: 200499-53-2
(R)-5-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)pyrrolidin-2-one

: 1399282-38-2
(R)-2-phenyl-1-((R)-pyrrolidin-2-yl)ethanol

Guidance literature:: Multi-step reaction with 4 steps

1: hydrogenchloride / ethanol / 2 h / 20 °C / Inert atmosphere

2: triphenylphosphine; di-isopropyl azodicarboxylate / chloroform / 36 h / Inert atmosphere; Reflux

3: copper(l) iodide / tetrahydrofuran; diethyl ether; pentane / 2 h / -35 °C / Inert atmosphere

4: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 0 °C / Inert atmosphere; Reflux

With hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; chloroform; pentane; 2: |Mitsunobu Displacement;
DOI:10.1039/c2ob26007g

Reference yield:

: 1399282-10-0
(R)-N,N-dibenzyl-1-((S)-2,2-dimethyl-1,3-dioxolan-4-yl)-prop-2-yn-1-amine

: 1399282-38-2
(R)-2-phenyl-1-((R)-pyrrolidin-2-yl)ethanol

Guidance literature:: Multi-step reaction with 7 steps

1.1: n-butyllithium / diethyl ether; hexane / 0.5 h / -78 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: Pd(OH)2/C; hydrogen / ethanol / 24 h / 20 °C / 5171.62 Torr / Inert atmosphere

3.1: sodium ethanolate / ethanol / 2 h / Inert atmosphere; Reflux

4.1: hydrogenchloride / ethanol / 2 h / 20 °C / Inert atmosphere

5.1: triphenylphosphine; di-isopropyl azodicarboxylate / chloroform / 36 h / Inert atmosphere; Reflux

6.1: copper(l) iodide / tetrahydrofuran; diethyl ether; pentane / 2 h / -35 °C / Inert atmosphere

7.1: lithium aluminium tetrahydride / tetrahydrofuran / 8 h / 0 °C / Inert atmosphere; Reflux

With hydrogenchloride; copper(l) iodide; lithium aluminium tetrahydride; n-butyllithium; di-isopropyl azodicarboxylate; Pd(OH)2/C; hydrogen; sodium ethanolate; triphenylphosphine; In tetrahydrofuran; diethyl ether; ethanol; hexane; chloroform; pentane; 5.1: |Mitsunobu Displacement;
DOI:10.1039/c2ob26007g