Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester
CAS No.:168985-13-5
Molecular Formula:C₁₈H₂₄N₆O₁₀P₂S
Molecular Weight:578.436
Hs Code.:

Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

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Chemical Property of Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

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Technology Process of Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

There total 5 articles about Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 168985-12-4
Toluene-4-sulfonic acid (2R,3R,4R,5S)-2-(6-amino-purin-9-yl)-4-tert-butoxycarbonylamino-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

: 168985-13-5
Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

Guidance literature:: With trifluoroacetic acid; for 0.0833333h; Ambient temperature;

Reference yield:

: 67313-04-6
3'-N-Boc-amino-3'-desoxyadenosin

: 168985-13-5
Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 75 percent / pyridine, 4-dimethylaminopyridine

2: 68 percent / acetonitrile

3: 85 percent / CF₃CO₂H / 0.08 h / Ambient temperature

With pyridine; dmap; trifluoroacetic acid; In acetonitrile;

Reference yield:

: 2504-55-4,26315-51-5,32077-67-1,51014-76-7
3'-amino-3'-deoxyadenosine

: 168985-13-5
Toluene-4-sulfonic acid (2R,3R,4R,5S)-4-amino-2-(6-amino-purin-9-yl)-5-(hydroxy-phosphonomethyl-phosphinoyloxymethyl)-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / dimethylformamide

2: 75 percent / pyridine, 4-dimethylaminopyridine

3: 68 percent / acetonitrile

4: 85 percent / CF₃CO₂H / 0.08 h / Ambient temperature

With pyridine; dmap; trifluoroacetic acid; In N,N-dimethyl-formamide; acetonitrile;