(E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester

Base Information

Chemical Name:(E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester
CAS No.:182237-05-4
Molecular Formula:C₃₈H₅₃Cl₃N₄O₁₄
Molecular Weight:896.216
Hs Code.:

(E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester

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Chemical Property of (E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester

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Technology Process of (E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester

There total 1 articles about (E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3886-08-6
5-tert-butyl N-benzyloxycarbonyl-L-glutamate

: (E)-(2S,7S)-2-((S)-2-Amino-propionyloxy)-7-((R)-1-methoxycarbonyl-ethylcarbamoyl)-7-(2,2,2-trichloro-ethoxycarbonylamino)-hept-4-enoic acid butyl ester

: 182237-05-4
(E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester

Guidance literature:: With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; In dichloromethane; for 2h; Yield given; Ambient temperature;

Reference yield:

: 182237-05-4
(E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester

: (E)-(2S,6S)-6-Amino-2-[(S)-2-((S)-2-benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-hex-4-enoic acid butyl ester

Guidance literature:: With zinc; In tetrahydrofuran; for 2h; Ambient temperature; pH=4;

Reference yield:

: 182237-05-4
(E)-(2S,6S)-2-[(S)-2-((S)-2-Benzyloxycarbonylamino-4-tert-butoxycarbonyl-butyrylamino)-propionyloxy]-6-((R)-1-methoxycarbonyl-ethylcarbamoyl)-6-(2,2,2-trichloro-ethoxycarbonylamino)-hex-4-enoic acid butyl ester

: (E)-(3S,6S,11S,14S,17S,21S)-6-Benzyloxycarbonylamino-11-isobutyl-14-isopropyl-17-((R)-1-methoxycarbonyl-ethylcarbamoyl)-3-methyl-2,5,9,12,15-pentaoxo-1-oxa-4,10,13,16-tetraaza-cyclohenicos-18-ene-21-carboxylic acid butyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: Zn / tetrahydrofuran / 2 h / Ambient temperature; pH=4

2: (Benzotriazol-1-oxy)-tris-(dimethylamino)phosphoniumhexafluorphosphonat, N-Methylmorpholin / CH₂Cl₂ / 12 h / Ambient temperature

3: 1.) CF₃CO₂H, 2.) (Benzotriazol-1-oxy)-tris-(dimethylamino)phosphoniumhexafluorphosphonat, N-Methylmorpolin / 1.) CH₂Cl₂, RT, 20 min, 2.) CH₂Cl₂, RT, 2 h

With 4-methyl-morpholine; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; trifluoroacetic acid; zinc; In tetrahydrofuran; dichloromethane;