5-Chloro-2-fluoro-4-methoxyphenylboronic acid

Base Information

• Chemical Name: 5-Chloro-2-fluoro-4-methoxyphenylboronic acid
• CAS No.: 677741-96-7
• Molecular Formula: C7H7BClFO3
• Molecular Weight: 204.39
• Mol file: 677741-96-7.mol

Synonyms:(5-Chloro-2-fluoro-4-methoxy-phenyl)boronic acid;

Chemical Property of 5-Chloro-2-fluoro-4-methoxyphenylboronic acid

Chemical Property:

• Vapor Pressure: 7.73E-05mmHg at 25°C
• Refractive Index: 1.525
• Boiling Point: 328.3 °C at 760 mmHg
• Flash Point: 152.3 °C
• PSA: 49.69000
• Density: 1.4 g/cm³
• LogP: 0.16750

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Chloro-2-fluoro-4-methoxyphenylboronic acid

There total 1 articles about 5-Chloro-2-fluoro-4-methoxyphenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-chloro-4-fluoro-2-iodo-5-methoxy-benzene (677741-99-0) → 2-chloro-5-fluoro-4-methoxyphenylboronic acid (677741-96-7)

Guidance literature:

1-chloro-4-fluoro-2-iodo-5-methoxy-benzene; With n-butyllithium; boron hydroxide; In tetrahydrofuran; hexane; at -78 - 20 ℃;

With hydrogenchloride; at 20 ℃; for 1h;

Reference yield: 63.0%

2-chloro-5-fluoro-4-methoxyphenylboronic acid (677741-96-7) + 2-benzyloxy-4-chloro-3-nitropyridine (219735-84-9) → 2-Benzyloxy-4-(2-chloro-5-fluoro-4-methoxy-phenyl)-3-nitro-pyridine (677743-43-0)

Guidance literature:

upstream raw materials:

1-chloro-4-fluoro-2-iodo-5-methoxy-benzene

Downstream raw materials:

2-Benzyloxy-4-(2-chloro-5-fluoro-4-methoxy-phenyl)-3-nitro-pyridine

Refernces