5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester

Base Information

Chemical Name:5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester
CAS No.:194143-49-2
Molecular Formula:C₄₁H₅₄BrN₅O₁₂S
Molecular Weight:920.876
Hs Code.:

5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester

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Chemical Property of 5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester

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Technology Process of 5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester

There total 12 articles about 5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2389-60-8
Z-Lys(Boc)-OH

: 194143-49-2
5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: BOP, HOBt, NMM / dimethylformamide

2: H₂ / Pd/C / ethyl acetate

3: Et₃N / dimethylformamide

4: NaOH / ethanol

5: BOP, HOBt, NMM / dimethylformamide

With 4-methyl-morpholine; sodium hydroxide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo970866w

Reference yield:

: 3182-93-2
(L)-phenylalanine ethyl ester hydrochloride

: 194143-49-2
5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: BOP, HOBt, NMM / dimethylformamide

2: H₂ / Pd/C / ethyl acetate

3: Et₃N / dimethylformamide

4: NaOH / ethanol

5: BOP, HOBt, NMM / dimethylformamide

With 4-methyl-morpholine; sodium hydroxide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo970866w

Reference yield:

: 25126-62-9
Z-Lys(Boc)-Phe-OC₂H₅

: 194143-49-2
5-[4-(1-{(S)-2-[(S)-2-(4-Bromo-benzenesulfonylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-phenyl-propionylamino}-ethyl)-2-methoxy-5-nitro-phenoxy]-pentanoic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pd/C / ethyl acetate

2: Et₃N / dimethylformamide

3: NaOH / ethanol

4: BOP, HOBt, NMM / dimethylformamide

With 4-methyl-morpholine; sodium hydroxide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In ethanol; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jo970866w