{2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester

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Chemical Name:{2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester
CAS No.:128404-16-0
Molecular Formula:C₄₀H₅₅N₇O₁₂
Molecular Weight:825.916
Hs Code.:

{2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester

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Chemical Property of {2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester

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Technology Process of {2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester

There total 5 articles about {2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2212-69-3
N₂-benzyloxycarbonyl-N₆-t-butoxycarbonyl-L-lysine 4-nitrophenyl ester

: 128404-16-0
{2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / benzyltrimethylammonium hydroxide / dimethylformamide / 24 h / Ambient temperature

2: 1.) H₂, 2.) 1N NaOH / 1.) Pd-C / 1.) MeOH, H₂O, 2.) dioxane, RT, 1 day

3: 1.) CF₃COOH, 2.) diphenylphosphoryl azide, N-ethylmorpholine / 1.) CH₂Cl₂, 0 deg C, 2.) DMF, 0 deg C, then RT

With N-ethylmorpholine;; sodium hydroxide; diphenylphosphoranyl azide; hydrogen; N-benzyl-trimethylammonium hydroxide; trifluoroacetic acid; palladium on activated charcoal; In N,N-dimethyl-formamide;

Reference yield:

: 1738-82-5
glycylglycine benzyl ester p-toluene sulfonate salt

: 128404-16-0
{2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / Et₃N / dimethylformamide / Ambient temperature

2: 1.) CF₃COOH, 2.) diphenylphosphoryl azide, N-ethylmorpholine / 1.) CH₂Cl₂, 0 deg C, 2.) DMF, 0 deg C, then RT

With N-ethylmorpholine;; diphenylphosphoranyl azide; triethylamine; trifluoroacetic acid; In N,N-dimethyl-formamide;

Reference yield:

: 128404-11-5
N^α-benzyloxycarbonyl-N^ε-tert-butyloxycarbonyl-lysyl-serine

: 128404-16-0
{2-[((S)-1-{(S)-2-[(S)-2-(2-Benzyloxycarbonylamino-acetylamino)-6-tert-butoxycarbonylamino-hexanoylamino]-3-hydroxy-propionyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-acetic acid benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) H₂, 2.) 1N NaOH / 1.) Pd-C / 1.) MeOH, H₂O, 2.) dioxane, RT, 1 day

2: 1.) CF₃COOH, 2.) diphenylphosphoryl azide, N-ethylmorpholine / 1.) CH₂Cl₂, 0 deg C, 2.) DMF, 0 deg C, then RT

With N-ethylmorpholine;; sodium hydroxide; diphenylphosphoranyl azide; hydrogen; trifluoroacetic acid; palladium on activated charcoal;