2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Chemical Name:2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide
CAS No.:1428533-69-0
Molecular Formula:C₃₂H₂₉BrClF₃N₆O₆S
Molecular Weight:798.037
Hs Code.:

2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Chemical Property of 2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

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Technology Process of 2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

There total 7 articles about 2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 27200-79-9
p-bromophenylacetaldehyde

: 1428533-69-0
2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: N-ethyl-N,N-diisopropylamine / dichloromethane; dimethyl sulfoxide / 0.02 h / 20 °C

1.2: 1 h / Reflux

2.1: hydrogenchloride / diethyl ether / 0.08 h

2.2: Reflux

3.1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.67 h / Reflux

4.1: potassium carbonate; water / acetonitrile / 0.25 h / 100 °C / Microwave irradiation

5.1: pyridine; trichlorophosphate / 1.5 h / -15 - 20 °C / Inert atmosphere

With pyridine; hydrogenchloride; water; palladium diacetate; potassium carbonate; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In 1,2-dimethoxyethane; diethyl ether; dichloromethane; dimethyl sulfoxide; acetonitrile; 1.1: |Strecker Aminoacid Synthesis / 1.2: |Strecker Aminoacid Synthesis;
DOI:10.1021/jm301887f

Reference yield:

: 1428533-31-6
benzyl 2-(6-(4-bromobenzyl)-3,5-dichloro-2-oxopyrazin-1(2H)-yl)acetate

: 1428533-69-0
2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: Multi-step reaction with 3 steps

1: palladium diacetate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,2-dimethoxyethane / 0.67 h / Reflux

2: potassium carbonate; water / acetonitrile / 0.25 h / 100 °C / Microwave irradiation

3: pyridine; trichlorophosphate / 1.5 h / -15 - 20 °C / Inert atmosphere

With pyridine; water; palladium diacetate; potassium carbonate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; trichlorophosphate; In 1,2-dimethoxyethane; acetonitrile;
DOI:10.1021/jm301887f

Reference yield:

: 1428533-48-5
benzyl 2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetate

: 1428533-69-0
2-(2-(6-(4-bromobenzyl)-3-(3-(tert-butyl)ureido)-5-chloro-2-oxopyrazin-1(2H)-yl)acetamido)-N-((4-(trifluoromethyl)phenyl)sulfonyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate; water / acetonitrile / 0.25 h / 100 °C / Microwave irradiation

2: pyridine; trichlorophosphate / 1.5 h / -15 - 20 °C / Inert atmosphere

With pyridine; water; potassium carbonate; trichlorophosphate; In acetonitrile;
DOI:10.1021/jm301887f