C₃₀H₃₃FO₄

Base Information

• Chemical Name: C₃₀H₃₃FO₄
• CAS No.: 1142214-45-6
• Molecular Formula: C₃₀H₃₃FO₄
• Molecular Weight: 476.588
• Mol file: 1142214-45-6.mol

Synonyms:

Chemical Property of C₃₀H₃₃FO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₀H₃₃FO₄

There total 11 articles about C₃₀H₃₃FO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester (39778-63-7) → C30H33FO4 (1142214-45-6)

Guidance literature:

Multi-step reaction with 6 steps

1: triethylamine; dmap / dichloromethane / 19 h / 23 °C

2: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C

3: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

4: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C

5: caesium carbonate / N,N-dimethyl-formamide

6: lithium hydroxide / ethanol; water

With dmap; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium carbonate; caesium carbonate; triethylamine; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 2: |Suzuki-Miyaura Coupling;

DOI:10.1021/ml300133f

Reference yield:

methyl 2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate (1142223-12-8) → C30H33FO4 (1142214-45-6)

Guidance literature:

Multi-step reaction with 4 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

2: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C

3: caesium carbonate / N,N-dimethyl-formamide

4: lithium hydroxide / ethanol; water

With lithium aluminium tetrahydride; thionyl chloride; caesium carbonate; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;

DOI:10.1021/ml300133f

Reference yield:

methyl 3-tert-butyl-4-(trifluoromethylsulfonyloxy)benzoate (1142223-10-6) → C30H33FO4 (1142214-45-6)

Guidance literature:

Multi-step reaction with 5 steps

1: potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 2 h / 100 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: thionyl chloride / dichloromethane / 18 h / 0 - 20 °C

4: caesium carbonate / N,N-dimethyl-formamide

5: lithium hydroxide / ethanol; water

With lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; thionyl chloride; potassium carbonate; caesium carbonate; lithium hydroxide; In tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; 1: |Suzuki-Miyaura Coupling;

DOI:10.1021/ml300133f

upstream raw materials:

3-(1,1-dimethylethyl)-4-hydroxybenzoic acid methyl ester

methyl 3-tert-butyl-4-(trifluoromethylsulfonyloxy)benzoate

methyl 2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-carboxylate

(2-(1,1-dimethylethyl)-2'-fluoro-5'-(methyloxy)-1,1'-biphenyl-4-yl)methanol