4-Difluoromethyl-phenylboronic acid

Base Information

• Chemical Name: 4-Difluoromethyl-phenylboronic acid
• CAS No.: 946525-43-5
• Molecular Formula: C7H7BF2O2
• Molecular Weight: 171.939
• Hs Code.: 2931900090
• Mol file: 946525-43-5.mol

Synonyms:4-Difluoromethyl-phenylboronic acid;4-Borono-alpha,alpha-difluorotoluene, 4-Boronobenzal fluoride;4-Boronobenzal fluoride

Chemical Property of 4-Difluoromethyl-phenylboronic acid

Chemical Property:

• Boiling Point: 287℃
• PKA: 8.36±0.17(Predicted)
• Flash Point: 127℃
• PSA: 40.46000
• Density: 1.27
• LogP: 0.30400
• Storage Temp.: Refrigerated.

Purity/Quality:

97% ^*data from raw suppliers

4-Difluoromethylphenylboronicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Difluoromethylphenylboronic acid

Technology Process of 4-Difluoromethyl-phenylboronic acid

There total 1 articles about 4-Difluoromethyl-phenylboronic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ (4-(difluoromethyl)phenyl)boronic acid (946525-43-5)

Guidance literature:

Reference yield: 89.0%

(4-(difluoromethyl)phenyl)boronic acid (946525-43-5) + (3-bromo-5-fluorophenyl)(3,4,5-trimethoxyphenyl)methanone → (4′-(difluoromethyl)-5-fluoro-[1,1′-biphenyl]-3-yl)(3,4,5-trimethoxyphenyl)methanone

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,4-dioxane; water; Reflux; Inert atmosphere;

DOI:10.1021/acs.jmedchem.1c00715

Reference yield: 84.0%

(4-(difluoromethyl)phenyl)boronic acid (946525-43-5) + (2R)-4-(7-bromo-4-oxoquinazolin-3(4H)-yl)-2-methyl-2-(methylsulfonyl)-N-((tetrahydro-2H-pyran-2-yl)oxy)butanamide → (2R)-4-(7-(4-(difluoromethyl)phenyl)-4-oxoquinazolin-3(4H)-yl)-2-methyl-2-(methylsulfonyl)-N-((tetrahydro-2H-pyran-2-yl)oxy)butanamide

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; at 110 ℃; for 0.5h; Inert atmosphere;

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