Thiophosphoric acid S-[N-(4-adamantan-1-yl-benzyl)-carbamimidoylmethyl] ester

Base Information

• Chemical Name: Thiophosphoric acid S-[N-(4-adamantan-1-yl-benzyl)-carbamimidoylmethyl] ester
• CAS No.: 724416-54-0
• Molecular Formula: C₁₉H₂₇N₂O₃PS
• Molecular Weight: 394.475
• Mol file: 724416-54-0.mol

Synonyms:

Chemical Property of Thiophosphoric acid S-[N-(4-adamantan-1-yl-benzyl)-carbamimidoylmethyl] ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Thiophosphoric acid S-[N-(4-adamantan-1-yl-benzyl)-carbamimidoylmethyl] ester

There total 5 articles about Thiophosphoric acid S-[N-(4-adamantan-1-yl-benzyl)-carbamimidoylmethyl] ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(adamant-1-yl)benzoic acid (7123-78-6) → Thiophosphoric acid S-[N-(4-adamantan-1-yl-benzyl)-carbamimidoylmethyl] ester (724416-54-0)

Guidance literature:

Multi-step reaction with 5 steps

1: PCl₅ / CCl₄ / 1 h / Heating

2: 75 percent / 28 percent ammonium hydroxide / benzene / 8 h / 0 °C

3: 78 percent / 1.) LiAlH₄ 2.) HCl gas / tetrahydrofuran / 24 h / Heating

4: 84 percent / HCl / methanol / 12 h

5: 1.) trisodium phosphorothioate 2.) 6 N HCl / 1.) 50 percent aq. EtOH, ambient temp., 30 min, 2.) 90 deg C, 20 min

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; phosphorus pentachloride; trisodium thiophosphate; In tetrahydrofuran; methanol; tetrachloromethane; benzene;

DOI:10.1016/S0040-4020(01)90332-1

Reference yield:

4-(1-adamantyl)benzamide (117101-74-3) → Thiophosphoric acid S-[N-(4-adamantan-1-yl-benzyl)-carbamimidoylmethyl] ester (724416-54-0)

Guidance literature:

Multi-step reaction with 3 steps

1: 78 percent / 1.) LiAlH₄ 2.) HCl gas / tetrahydrofuran / 24 h / Heating

2: 84 percent / HCl / methanol / 12 h

3: 1.) trisodium phosphorothioate 2.) 6 N HCl / 1.) 50 percent aq. EtOH, ambient temp., 30 min, 2.) 90 deg C, 20 min

With hydrogenchloride; lithium aluminium tetrahydride; trisodium thiophosphate; In tetrahydrofuran; methanol;

DOI:10.1016/S0040-4020(01)90332-1

Reference yield:

4-(1-adamantyl)benzoic acid chloride (175881-22-8) → Thiophosphoric acid S-[N-(4-adamantan-1-yl-benzyl)-carbamimidoylmethyl] ester (724416-54-0)

Guidance literature:

Multi-step reaction with 4 steps

1: 75 percent / 28 percent ammonium hydroxide / benzene / 8 h / 0 °C

2: 78 percent / 1.) LiAlH₄ 2.) HCl gas / tetrahydrofuran / 24 h / Heating

3: 84 percent / HCl / methanol / 12 h

4: 1.) trisodium phosphorothioate 2.) 6 N HCl / 1.) 50 percent aq. EtOH, ambient temp., 30 min, 2.) 90 deg C, 20 min

With hydrogenchloride; ammonium hydroxide; lithium aluminium tetrahydride; trisodium thiophosphate; In tetrahydrofuran; methanol; benzene;

DOI:10.1016/S0040-4020(01)90332-1

upstream raw materials:

N-(4-Adamantan-1-yl-benzyl)-2-chloro-acetamidine; hydrochloride

4-(adamant-1-yl)benzoic acid

4-(1-adamantyl)benzamide

4-(1-adamantyl)benzoic acid chloride