Technology Process of 3-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(4-fluoro-phenyl)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one
There total 6 articles about 3-((2R,3R,4S,5R)-3,4-Dihydroxy-5-hydroxymethyl-tetrahydro-furan-2-yl)-5-(4-fluoro-phenyl)-3H-[1,2,4]triazolo[1,5-a]pyrimidin-7-one which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 2.4 g / acetic acid / 2 h / Heating
2: 1. 1,1,1,3,3,3-hexamethyldisilazane / 1. N,N-dimethylformamide, 155 deg C for 16 h; 2. acetonitrile, 48 h at room temperature
3: ammonia in methanol / Ambient temperature; in sealed container overnight
With
ammonia methyl alcohol; 1,1,1,3,3,3-hexamethyl-disilazane;
In
acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: hydrogen bromide (solution in dichloromethane) / CH2Cl2 / from -20 deg C to room temperature
2: 1. 1,1,1,3,3,3-hexamethyldisilazane / 1. N,N-dimethylformamide, 155 deg C for 16 h; 2. acetonitrile, 48 h at room temperature
3: ammonia in methanol / Ambient temperature; in sealed container overnight
With
hydrogen bromide; ammonia methyl alcohol; 1,1,1,3,3,3-hexamethyl-disilazane;
In
dichloromethane;
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic acid / 2 h / Heating
2: 1. 1,1,1,3,3,3-hexamethyldisilazane / 1. N,N-dimethylformamide, 155 deg C for 16 h; 2. acetonitrile, 48 h at room temperature
3: ammonia in methanol / Ambient temperature; in sealed container overnight
With
ammonia methyl alcohol; 1,1,1,3,3,3-hexamethyl-disilazane;
In
acetic acid;
