3,5-DICHLOROINDOLE

Base Information

• Chemical Name: 3,5-DICHLOROINDOLE
• CAS No.: 120258-33-5
• Molecular Formula: C8H5Cl2N
• Molecular Weight: 186.04
• Mol file: 120258-33-5.mol

Synonyms:3,5-DICHLOROINDOLE

Chemical Property of 3,5-DICHLOROINDOLE

Chemical Property:

• Boiling Point: 316.7±22.0 °C(Predicted)
• PKA: 14.51±0.30(Predicted)
• PSA: 15.79000
• Density: 1.479±0.06 g/cm3(Predicted)
• LogP: 3.47470

Purity/Quality:

98%min ^*data from raw suppliers

3,5-DICHLORO-1H-INDOLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3,5-DICHLOROINDOLE

There total 4 articles about 3,5-DICHLOROINDOLE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,5-dichloro-indole-1-sulfonic acid dimethylamide → 3,5-dichloroindole (120258-33-5)

Guidance literature:

With tetraethylammonium perchlorate; In N,N-dimethyl-formamide; at 20 ℃; Electrolysis;

DOI:10.1016/S0040-4039(00)01504-5

Reference yield: 85.0%

5-chloro-1H-indole (17422-32-1) → 3,5-dichloroindole (120258-33-5)

Guidance literature:

With N-chloro-succinimide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

DOI:10.1021/jo800116y

Reference yield: 75.0%

3-chloro-1H-indole (16863-96-0) → 3,5-dichloroindole (120258-33-5)

Guidance literature:

With N-Bromosuccinimide; In methanol; water; at 20 ℃; for 1h; regioselective reaction;

DOI:10.1039/d1nj02777h

upstream raw materials:

5-chloro-1H-indole

indole

3-chloro-1H-indole

Refernces

• 1、 Largeron,Farrell,Rousseau,Fleury,Potier,Dodd. "Efficient electrochemical cleavage of N,N-dimethylaminosulfonyl-protected indoles". . p. 9403 - 9406. Retrieved 2000.
• 2、 Himabindu, Vittam,Parvathaneni, Sai Prathima,Rao, Vaidya Jayathirtha. "PhI(OAc)2/NaX-mediated halogenation providing access to valuable synthons 3-haloindole derivatives". . p. 18889 - 18893. Retrieved 2018/11/27.