2,6-Dichloro-1,4-didihydropyridine-3,5-dicarboxyaldehyde

Base Information

• Chemical Name: 2,6-Dichloro-1,4-didihydropyridine-3,5-dicarboxyaldehyde
• CAS No.: 81305-72-8
• Molecular Formula: C₇H₅Cl₂NO₂
• Molecular Weight: 206.028
• Mol file: 81305-72-8.mol

Synonyms:2,6-Dichloro-1,4-didihydropyridine-3,5-dicarboxyaldehyde; 2,6-Dichloro-1,4-dihydropyridine-3,5-dicarboxaldehyde

Chemical Property of 2,6-Dichloro-1,4-didihydropyridine-3,5-dicarboxyaldehyde

Chemical Property:

• Melting Point: 166-168℃
• Boiling Point: 318℃
• PKA: -2.29±0.70(Predicted)
• Flash Point: 146℃
• PSA: 46.17000
• Density: 1.49
• LogP: 1.60710

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-Dichloro-1,4-didihydropyridine-3,5-dicarboxyaldehyde

There total 6 articles about 2,6-Dichloro-1,4-didihydropyridine-3,5-dicarboxyaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

piperidine-2,6-dione (1121-89-7) → 2,6-dichloro-3-formylpyridine-5-carboxaldehyde (81319-42-8) + 2,6-Dichlor-3,5-diformyl-1,4-dihydro-pyridin (81305-72-8)

Guidance literature:

With N,N-dimethyl-formamide; trichlorophosphate; at 100 ℃;

Reference yield: 63.0%

piperidine-2,6-dione (1121-89-7) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → 2,6-Dichlor-3,5-diformyl-1,4-dihydro-pyridin (81305-72-8)

Guidance literature:

With trichlorophosphate; for 1h; Ambient temperature; another 1.5 h heating in a 100 deg C bath;

Reference yield:

2,6-dichloro-3-((dimethylamino)methylene)-3,4.dihydropyridine-5-carboxaldehyde (129216-00-8) → 2,6-Dichlor-3,5-diformyl-1,4-dihydro-pyridin (81305-72-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; acetone; Yield given; Ambient temperature; 0.25-0.5 h;

DOI:10.1021/jo00309a026

upstream raw materials:

piperidine-2,6-dione

N,N-dimethyl-formamide

glutaramic acid

2,6-dichloro-3-((dimethylamino)methylene)-3,4.dihydropyridine-5-carboxaldehyde

Downstream raw materials:

2,6-dichloro-3-formylpyridine-5-carboxaldehyde

Refernces

• 1、 Kurfuerst, Antonin,Sebek, Pavel. "ON REACTIVITY OF 2,6-DICHLORO-3,5-DIFORMYL-1,4,4-TRIMETHYL-1,4-DIHYDROPYRIDINE". . p. 1705 - 1715. Retrieved 2007/10/02.