N_α-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid

Base Information

Chemical Name:N_α-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid
CAS No.:109923-94-6
Molecular Formula:BrH*C₁₅H₁₇N₃O₃
Molecular Weight:368.23
Hs Code.:

N<sub>α</sub>-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid

Synonyms:

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N_α-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid

Chemical Property:

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Technology Process of N_α-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid

There total 1 articles about N_α-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 107994-40-1
N_α-(Benzyloxycarbonyl-L-prolyl)-D,L-4-cyanphenylalanin

: 109923-94-6
N_α-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid

Guidance literature:: With hydrogen bromide; In acetic acid;

Reference yield:

: 109923-94-6
N_α-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid

: 109968-87-8,109982-39-0
(S)-1-[2-(Toluene-4-sulfonylamino)-acetyl]-pyrrolidine-2-carboxylic acid [1-(4-carbamimidoyl-benzyl)-2-oxo-2-piperidin-1-yl-ethyl]-amide; hydriodide

Guidance literature:: Multi-step reaction with 5 steps

1: NaOH / diethyl ether / 2 h

2: 1) ethylmorpholine, isobutyl chlorocarbonate / 1) ethyl acetate, 15 min, 0 deg C, 2) 2 h

3: 60 percent / TEA, H₂S / pyridine / 72 h / Ambient temperature

4: 55 percent / acetone / 0.25 h / Heating

5: 75 percent / CH₃COONH₄ / methanol / 3 h / 60 °C

With 2-ethylmorpholine; sodium hydroxide; TEA; hydrogen sulfide; ammonium acetate; isobutyl chloroformate; In pyridine; methanol; diethyl ether; acetone;

Reference yield:

: 109923-94-6
N_α-(L-Prolyl)-D,L-4-cyanphenylalaninhydrobromid

: 109968-85-6,109969-00-8
4-[3-Oxo-3-pyrrolidin-1-yl-2-({(S)-1-[2-(toluene-4-sulfonylamino)-acetyl]-pyrrolidine-2-carbonyl}-amino)-propyl]-thiobenzimidic acid methyl ester; hydriodide

Guidance literature:: Multi-step reaction with 4 steps

1: NaOH / diethyl ether / 2 h

2: 1) ethylmorpholine, isobutyl chlorocarbonate / 1) ethyl acetate, 15 min, 0 deg C, 2) 2 h

3: 65 percent / TEA, H₂S / pyridine / 72 h / Ambient temperature

4: 80 percent / acetone / 0.25 h / Heating

With 2-ethylmorpholine; sodium hydroxide; TEA; hydrogen sulfide; isobutyl chloroformate; In pyridine; diethyl ether; acetone;