L-Threoascorbic acid-1-13C

Base Information

• Chemical Name: L-Threoascorbic acid-1-13C
• CAS No.: 178101-88-7
• Molecular Formula: C6H8O6
• Molecular Weight: 176.12412
• Mol file: 178101-88-7.mol

Synonyms:L-Ascorbic acid-1-13C;L-Threoascorbic acid-1-13C;VITAMIN C (L-ASCORBIC ACID) (1-13C, 99%)

Chemical Property of L-Threoascorbic acid-1-13C

Chemical Property:

• Melting Point: 193 °C (dec. )(lit.)
• Storage Temp.: -20°C Freezer, Under inert atmosphere
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

L-Ascorbic Acid-1-13C ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: L-Threoascorbic acid-1-13C is coenzyme for a number of hydroxylation reactions; required for collagen synthesis. Widely distributed in plants and animals. Inadequate intake results in deficiency syndromes such as scurvy. Used as antimicrobial and antioxidant in foodstuffs.

Technology Process of L-Threoascorbic acid-1-13C

There total 2 articles about L-Threoascorbic acid-1-13C which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

L-xylosone (3445-23-6) + [13C]-potassium cyanide (25909-68-6) → [1-13C]ascorbic acid (178101-88-7)

Guidance literature:

With Dowex HCR-W₂ resin (H(+)-form); water; acetic acid; Yield given. Multistep reaction; 1.) 10 min, 2.) reflux, 1.5 h;

DOI:10.1016/0008-6215(96)00008-0

Reference yield:

[1-13C]dehydroascorbic acid (1159923-26-8) → 1-(13)C-diketogulonic acid + [1-13C]ascorbic acid (178101-88-7)

Guidance literature:

With glutaredoxin; ethylenediaminetetraacetic acid; GLUTATHIONE; thiol-disulfide oxidoreductase; protein disulfide isomerase; pH=7.4; Concentration; Kinetics; aq. phosphate buffer; Enzymatic reaction;

DOI:10.1021/ja2045925

upstream raw materials:

L-xylosone

[¹³C]-potassium cyanide

[1-¹³C]dehydroascorbic acid