3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine

Base Information

Chemical Name:3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine
CAS No.:122253-81-0
Molecular Formula:C₄₇H₅₂FNO₃Si
Molecular Weight:726.019
Hs Code.:

3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine

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Chemical Property of 3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine

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Technology Process of 3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine

There total 7 articles about 3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 122253-39-8
3-Bromomethyl-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine

: 122253-81-0,123930-26-7
3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene / 5 h / Heating

2: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With n-butyllithium; In toluene;
DOI:10.1021/jm00163a010

Reference yield:

: 122253-16-1
[2-Cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridin-3-yl]-methanol

: 122253-81-0,123930-26-7
3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 3 steps

1: PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

2: toluene / 5 h / Heating

3: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With n-butyllithium; phosphorus tribromide; In dichloromethane; toluene;
DOI:10.1021/jm00163a010

Reference yield:

: 122252-80-6
2-Cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-nicotinic acid ethyl ester

: 122253-81-0,123930-26-7
3-{(Z)-2-[(2S,4R,6R)-4-(tert-Butyl-diphenyl-silanyloxy)-6-methoxy-tetrahydro-pyran-2-yl]-vinyl}-2-cyclohexyl-4-(4-fluoro-phenyl)-6-phenyl-pyridine

Guidance literature:: Multi-step reaction with 4 steps

1: LiAlH₄ / tetrahydrofuran / 1.5 h / Ambient temperature

2: PBr₃ / toluene; CH₂Cl₂ / 1 h / Ambient temperature

3: toluene / 5 h / Heating

4: 1.) 1.6 M n-BuLi / 1.) THF, hexane, 0.5 h, 2.) 1 h

With lithium aluminium tetrahydride; n-butyllithium; phosphorus tribromide; In tetrahydrofuran; dichloromethane; toluene;
DOI:10.1021/jm00163a010