alpha-APP Modulator

Base Information

Chemical Name:alpha-APP Modulator
CAS No.:497259-23-1
Molecular Formula:C27H30F3N3O3
Molecular Weight:501.54
Hs Code.:
DSSTox Substance ID:DTXSID60433032
Wikidata:Q72481853
Pharos Ligand ID:Y18CY6A1G68S
ChEMBL ID:CHEMBL331344
Mol file:497259-23-1.mol

Synonyms:tppb;497259-23-1;alpha-APP Modulator;(2S,5S)-(E,E)-8-(5-(4-(Trifluoromethyl)phenyl)-2,4-pentadienoylamino)benzolactam;CHEMBL331344;ALPHA-AMYLOID PRECURSOR PROTEIN MODULATOR;(2E,4E)-N-[(2S,5S)-1,2,3,4,5,6-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3-oxo-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]-2,4-pentadienamide;(2E,4E)-N-((2S,5S)-5-(hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydrobenzo[e][1,4]diazocin-8-yl)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide;PKC Activator V;SCHEMBL22718964;DTXSID60433032;WOLVEMPZUIFSII-IHHOKICGSA-N;BCPP000037;EX-A2507;BDBM50122940;AKOS030527657;CS-7939;(2E,4E)-N-[(2S,5S)-5-(hydroxymethyl)-1-methyl-3-oxo-2-propan-2-yl-2,4,5,6-tetrahydro-1,4-benzodiazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide;AC-36105;AS-82981;HY-12359;alpha -Amyloid Precursor Protein Modulator;A871735;(2E,4E)-N-[(2S,5R)-5-(hydroxymethyl)-1-methyl-3-oxo-2-(propan-2-yl)-1,2,3,4,5,6-hexahydro-1-benzazocin-8-yl]-5-[4-(trifluoromethyl)phenyl]penta-2,4-dienamide;5-(4-Trifluoromethyl-phenyl)-penta-2,4-dienoic acid (5-hydroxymethyl-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydro-benzo[e][1,4]diazocin-8-yl)-amide

Suppliers and Price of alpha-APP Modulator

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
TPPB
2.5mg
$ 615.00

TRC
TPPB
1mg
$ 285.00

Tocris
TPPB ≥98%(HPLC)
1
$ 145.00

DC Chemicals
α-AmyloidPrecursorProteinModulator >98%
25 mg
$ 1700.00

ChemScene
TPPB 99.81%
5mg
$ 800.00

ChemScene
TPPB 99.81%
10mg
$ 1350.00

ChemScene
TPPB 99.81%
1mg
$ 200.00

ApexBio Technology
(2E,4E)-N-(5-(hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydrobenzo[e][1,4]diazocin-8-yl)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide
1mg
$ 233.00

ApexBio Technology
(2E,4E)-N-(5-(hydroxymethyl)-2-isopropyl-1-methyl-3-oxo-1,2,3,4,5,6-hexahydrobenzo[e][1,4]diazocin-8-yl)-5-(4-(trifluoromethyl)phenyl)penta-2,4-dienamide
10mM (in 1mL DMSO)
$ 1283.00

American Custom Chemicals Corporation
ALPHA-AMYLOID PRECURSOR PROTEIN MODULATOR 95.00%
1MG
$ 876.65

Total 19 raw suppliers

Chemical Property of alpha-APP Modulator

Chemical Property:

Boiling Point:728.8±60.0 °C(Predicted)
PKA:12.76±0.60(Predicted)
PSA：85.16000
Density:1.229
LogP:4.82140
XLogP3:5
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:6
Exact Mass:501.22392631
Heavy Atom Count:36
Complexity:806

Purity/Quality:

99%, ^*data from raw suppliers

TPPB ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC(C)C1C(=O)NC(CC2=C(N1C)C=CC(=C2)NC(=O)C=CC=CC3=CC=C(C=C3)C(F)(F)F)CO
Isomeric SMILES:CC(C)[C@H]1C(=O)N[C@@H](CC2=C(N1C)C=CC(=C2)NC(=O)/C=C/C=C/C3=CC=C(C=C3)C(F)(F)F)CO
Uses TPPB is a protein kinase C (PKC) activator.

Technology Process of alpha-APP Modulator

There total 1 articles about alpha-APP Modulator which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%