N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide

Base Information

Chemical Name:N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide
CAS No.:102963-74-6
Molecular Formula:C₃₇H₅₉NO₅Si
Molecular Weight:625.965
Hs Code.:

N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide

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Chemical Property of N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide

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Technology Process of N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide

There total 1 articles about N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 79691-11-5,82978-03-8
6(R)-<2-<1,2,6,7,8,8a(R)-Hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutyryl>oxy>-1(S)-naphtyl>ethyl>-3,4,5,6-tetrahydro-4(R)-<(tert-butyldimethylsilyl)oxy>-2H-pyran-2-one

: 100-46-9
benzylamine

: 102963-74-6
N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide

Guidance literature:: In methanol; for 18h; Heating;
DOI:10.1021/jo00375a032

Reference yield: 68.0%

: 102963-74-6
N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide

: 103063-54-3,82978-03-8
6(S)-<2-<8(S)-<<2(S)-methylbutanoyl>oxy>-2(S),6(R)-dimethyl-1,2,6,7,8,8a(R)-hexahydro-1(S)-naphthyl>ethyl>-4-(R)-<(tert-butyldimethylsilyl)oxy>-3,4,5,6-tetrahydro-2H-pyran-2-one

Guidance literature:: With methanesulfonyl chloride; triethylamine; In dichloromethane; 1.) 3 h, 2.) RT, 8 h;
DOI:10.1021/jo00375a032

Reference yield:

: 102963-74-6
N-benzyl 7-<1,2,6,7,8,8a(R)-hexahydro-2(S),6(R)-dimethyl-8(S)-<<2(S)-methylbutanoyl>oxy>-1(S)-naphthyl>-3(R)-<(tert-butyldimethylsilyl)oxy>-5(R)-hydroxyheptanoic acid amide

: 105227-52-9
(S)-2-Methyl-butyric acid (1S,3R,7S,8S,8aR)-3,7-dimethyl-8-(2-{(2S,4R)-4-[2-(4-nitro-phenyl)-acetoxy]-6-oxo-tetrahydro-pyran-2-yl}-ethyl)-1,2,3,7,8,8a-hexahydro-naphthalen-1-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 68 percent / triethylamine, methanesulfonyl chloride / CH₂Cl₂ / 1.) 3 h, 2.) RT, 8 h

2: 68 percent / HOAc, tetra n-butylammonium fluoride / methanol / Ambient temperature

3: pyridine / Ambient temperature

With pyridine; tetrabutyl ammonium fluoride; acetic acid; methanesulfonyl chloride; triethylamine; In methanol; dichloromethane;
DOI:10.1021/jo00375a032