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Technology Process of Met Kinase Inhibitor

Met Kinase Inhibitor

Base Information
  • Chemical Name:Met Kinase Inhibitor
  • CAS No.:658084-23-2
  • Molecular Formula:C28H30ClN5O4S
  • Molecular Weight:568.096
  • Hs Code.:
  • European Community (EC) Number:636-258-1
  • NSC Number:747693
  • DSSTox Substance ID:DTXSID20429552
  • Nikkaji Number:J2.563.453E
  • Wikidata:Q27088888
  • Pharos Ligand ID:61PK4VXTPFBT
  • ChEMBL ID:CHEMBL261641
  • Mol file:658084-23-2.mol
Met Kinase Inhibitor

Synonyms:((3Z)-N-(3-chlorophenyl)-3-((3,5-dimethyl-4-((4-methylpiperazin-1-yl)carbonyl)-1H-pyrrol-2-yl)methylene)-N-methyl-2-oxo-2,3-dihydro-1H-indole-5-sulfonamide);SU 11274;SU11274

Suppliers and Price of Met Kinase Inhibitor
Supply Marketing:
Business phase:
The product has achieved commercial mass production*data from LookChem market partment
Manufacturers and distributors:
  • Manufacture/Brand
  • Chemicals and raw materials
  • Packaging
  • price
  • TRC
  • SU 11274
  • 1mg
  • $ 130.00
  • Sigma-Aldrich
  • Met Kinase Inhibitor
  • 1mg
  • $ 119.32
  • Sigma-Aldrich
  • SU 11274 ≥98% (HPLC), powder
  • 5mg
  • $ 211.00
  • Sigma-Aldrich
  • SU 11274 ≥98% (HPLC), powder
  • 25mg
  • $ 838.00
  • DC Chemicals
  • SU11274(PKI-SU11274) >98%
  • 250 mg
  • $ 800.00
  • DC Chemicals
  • SU11274(PKI-SU11274) >98%
  • 1 g
  • $ 1600.00
  • ChemScene
  • SU 11274 98.19%
  • 100mg
  • $ 858.00
  • ChemScene
  • SU 11274 98.19%
  • 50mg
  • $ 677.00
  • ChemScene
  • SU 11274 98.19%
  • 10mg
  • $ 185.00
  • Cayman Chemical
  • SU 11274 ≥95%
  • 5mg
  • $ 115.00
Total 41 raw suppliers
Chemical Property of Met Kinase Inhibitor
Chemical Property:
  • Appearance/Colour:orange powder 
  • Refractive Index:1.664 
  • PKA:11.62±0.20(Predicted) 
  • PSA：114.20000 
  • Density:1.401 g/cm3 
  • LogP:5.08490 
  • Storage Temp.:2-8°C 
  • Solubility.:DMSO: 10 mg/mL at 60 °C 
  • XLogP3:3.1
  • Hydrogen Bond Donor Count:2
  • Hydrogen Bond Acceptor Count:6
  • Rotatable Bond Count:5
  • Exact Mass:567.1707033
  • Heavy Atom Count:39
  • Complexity:1070
Purity/Quality:

99%, *data from raw suppliers

SU 11274 *data from reagent suppliers

Safty Information:
  • Pictogram(s): IrritantXi 
  • Hazard Codes:Xi 
  • Statements: 36/37/38 
  • Safety Statements: 26-36 
MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:
  • Canonical SMILES:CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)C=C3C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
  • Isomeric SMILES:CC1=C(NC(=C1C(=O)N2CCN(CC2)C)C)/C=C\3/C4=C(C=CC(=C4)S(=O)(=O)N(C)C5=CC(=CC=C5)Cl)NC3=O
  • Description MET is a proto-oncogene which encodes the hepatocyte growth factor receptor c-Met. It has normal roles in morphogenesis, migration, apoptosis, and angiogenesis. Dysregulation of c-Met occurs in many types of cancer. SU11274 is a potent, selective, ATP-competitive inhibitor of c-Met (IC50 = 20 nM). It has much less or no activity against other receptor tyrosine kinases. SU11274 induces apoptosis and cell cycle arrest in transformed Ba/F3 cells and cancer cell lines.
  • Uses SU 11274 is a competitive inhibitor of Met kinase activity.
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