Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester

Base Information

Chemical Name:Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester
CAS No.:219325-45-8
Molecular Formula:C₃₃H₃₈BrN₇O₉
Molecular Weight:756.61
Hs Code.:

Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester

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Chemical Property of Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester

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Technology Process of Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester

There total 9 articles about Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: Benzoic acid (R)-2-[(S)-2-((R)-3-amino-2-tert-butoxycarbonylamino-propionylamino)-3-carbamoyl-propionylamino]-1-[(S)-2-(5-bromo-1H-indol-3-yl)-1-carboxy-ethylcarbamoyl]-ethyl ester

: 219325-45-8
Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester

Guidance literature:: With pentafluorophenyl diphenyl-phosphinate; N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; Yield given;
DOI:10.1016/S0040-4039(98)02016-4

Reference yield:

: 7536-55-2,142847-17-4,75647-01-7
N-t-butyloxycarbonyl-D-asparagine

: 219325-45-8
Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester

Guidance literature:: Multi-step reaction with 5 steps

1: iodosobenzene diacetate / propan-1-ol; methyl acetate; H₂O / 0 deg C, 1 h; 50 deg C, 2 h

2: acetone; H₂O

3: (1H-benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, 1-hydroxybenzotriazole, N,N-diisopropylethylamine / dimethylformamide

4: TEA / dimethylformamide; CH₂Cl₂ / 2 h

5: N,N-diisopropylethylamine, pentafluorophenyldiphenylphosphinate / dimethylformamide

With [bis(acetoxy)iodo]benzene; TEA; pentafluorophenyl diphenyl-phosphinate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In propan-1-ol; dichloromethane; acetic acid methyl ester; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(98)02016-4

Reference yield:

: 73259-81-1,113625-76-6,76387-70-7
(R)-2-tert-butoxycarbonyl-3-aminopropionic acid

: 219325-45-8
Benzoic acid (3S,6R,10S,13R)-3-(5-bromo-1H-indol-3-ylmethyl)-13-tert-butoxycarbonylamino-10-carbamoylmethyl-2,5,9,12-tetraoxo-1,4,8,11-tetraaza-cyclotetradec-6-yl ester

Guidance literature:: Multi-step reaction with 4 steps

1: acetone; H₂O

2: (1H-benzotriazol-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate, 1-hydroxybenzotriazole, N,N-diisopropylethylamine / dimethylformamide

3: TEA / dimethylformamide; CH₂Cl₂ / 2 h

4: N,N-diisopropylethylamine, pentafluorophenyldiphenylphosphinate / dimethylformamide

With TEA; pentafluorophenyl diphenyl-phosphinate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine; In dichloromethane; water; N,N-dimethyl-formamide; acetone;
DOI:10.1016/S0040-4039(98)02016-4