Chemical Property of Buparlisib
Chemical Property:
- Boiling Point:645.7±65.0 °C(Predicted)
- PKA:5.94±0.50(Predicted)
- PSA：89.63000
- Density:1.382
- LogP:2.52400
- Storage Temp.:-20°C
- Solubility.:Soluble in DMSO (15 mg/ml)
- XLogP3:1.5
- Hydrogen Bond Donor Count:1
- Hydrogen Bond Acceptor Count:11
- Rotatable Bond Count:3
- Exact Mass:410.16780842
- Heavy Atom Count:29
- Complexity:530
- Purity/Quality:
-
99%, *data from raw suppliers
NVP-BKM120 *data from reagent suppliers
Safty Information:
- Pictogram(s):
- Hazard Codes:
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1COCCN1C2=NC(=NC(=C2)C3=CN=C(C=C3C(F)(F)F)N)N4CCOCC4
- Recent ClinicalTrials:LGX818 and MEK162 in Combination With a Third Agent (BKM120, LEE011, BGJ398 or INC280) in Advanced BRAF Melanoma
- Recent EU Clinical Trials:The BURAN Study of Buparlisib (AN2025) In Combination with Paclitaxel Compared to Paclitaxel Alone, in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
- Recent NIPH Clinical Trials:The BURAN Study of Buparlisib (AN2025) In Combination with Paclitaxel Compared to Paclitaxel Alone, in Patients with Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma
-
Description
Buparlisib (944396-07-0) is potent pan-Class I PI3-kinase inhibitor (IC50’s: p110α = 52 nM, p110? = 166 nM, p110δ = 116 nM. P110g = 262 nM).1,2 It inhibited microtubule dynamics at in vitro concentrations >1μM and doses above 50mg/kg in mice.3 Buparlisib lead to a precipitous drop in DNA synthesis in a mouse model of BRCA1-linked triple-negative breast cancer with less affect in normal tissue.4
-
Uses
NVP-BKM 120 is a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tu
mors in the brain or the spine. NVP-BKM 120 is a novel anti-tumor active compound that is selective in that it inhibits specifically PI3 kinase activating cell death in glioma cells. Glioma cells being those that proliferate from tumors in the brain or the spine.
