N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester

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Chemical Name:N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester
CAS No.:557111-48-5
Molecular Formula:C₄₁H₆₅IN₈O₈
Molecular Weight:924.92
Hs Code.:

N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester

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Chemical Property of N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester

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Technology Process of N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester

There total 5 articles about N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 557111-26-9
(4S,5S)-4-isobutyl-5-[(phenylmethyloxy)methyl]oxazolidin-2-one

: 557111-48-5
N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: 85 percent KOH / ethanol; H₂O / 8 h / Heating

1.2: 63 percent / DIEA / dimethylformamide / 24 h / 23 °C

2.1: H₂ / 10 percent Pd/C / methanol / 12 h / 23 °C

2.2: 54 percent / PPh₃; diethyl azodicarboxylate / CHCl₃ / 6 h / Heating

3.1: anisole / trifluoroacetic acid / 1 h / 4 °C

3.2: 65 percent / propan-2-ol / 4 h / 70 °C

4.1: 48 percent / DMAP / CHCl₃ / 12 h / 23 °C

With dmap; potassium hydroxide; hydrogen; methoxybenzene; palladium on activated charcoal; In methanol; ethanol; chloroform; water; trifluoroacetic acid; 2.2: Mitsunobu reaction;
DOI:10.1021/jo030063a

Reference yield:

: 557111-27-0
(2S,3S)-3-[N-(tert-butyloxycarbonyl)amino]-5-methyl-1-(phenylmethyloxy)hexan-2-ol

: 557111-48-5
N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: H₂ / 10 percent Pd/C / methanol / 12 h / 23 °C

1.2: 54 percent / PPh₃; diethyl azodicarboxylate / CHCl₃ / 6 h / Heating

2.1: anisole / trifluoroacetic acid / 1 h / 4 °C

2.2: 65 percent / propan-2-ol / 4 h / 70 °C

3.1: 48 percent / DMAP / CHCl₃ / 12 h / 23 °C

With dmap; hydrogen; methoxybenzene; palladium on activated charcoal; In methanol; chloroform; trifluoroacetic acid; 1.2: Mitsunobu reaction;
DOI:10.1021/jo030063a

Reference yield:

: 107202-52-8
(2S)-2-[(1S)-1-[N-(tert-butyloxycarbonyl)amino]-3-methylbutyl]oxirane

: 557111-48-5
N-Carbamoylmethyl-succinamic acid (1R,2S)-1-[(S)-2-(3-iodo-benzylcarbamoyl)-pyrrolidin-1-ylmethyl]-4-methyl-2-((2S,3S)-3-methyl-2-{(S)-3-methyl-2-[((S)-pyrrolidine-2-carbonyl)-amino]-butyrylamino}-pentanoylamino)-pentyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: anisole / trifluoroacetic acid / 1 h / 4 °C

1.2: 65 percent / propan-2-ol / 4 h / 70 °C

2.1: 48 percent / DMAP / CHCl₃ / 12 h / 23 °C

With dmap; methoxybenzene; In chloroform; trifluoroacetic acid;
DOI:10.1021/jo030063a