benzyl 13-(ethoxycarbonylmethyl)-3,8-diethyl-2,7,12,14-tetramethyl-5,6-dihydropyrrin-1-carboxylate hydrobromide

Base Information

• Chemical Name: benzyl 13-(ethoxycarbonylmethyl)-3,8-diethyl-2,7,12,14-tetramethyl-5,6-dihydropyrrin-1-carboxylate hydrobromide
• CAS No.: 129715-49-7
• Molecular Formula: BrH*C₃₄H₄₁N₃O₄
• Molecular Weight: 636.629
• Mol file: 129715-49-7.mol

Synonyms:

Chemical Property of benzyl 13-(ethoxycarbonylmethyl)-3,8-diethyl-2,7,12,14-tetramethyl-5,6-dihydropyrrin-1-carboxylate hydrobromide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of benzyl 13-(ethoxycarbonylmethyl)-3,8-diethyl-2,7,12,14-tetramethyl-5,6-dihydropyrrin-1-carboxylate hydrobromide

There total 3 articles about benzyl 13-(ethoxycarbonylmethyl)-3,8-diethyl-2,7,12,14-tetramethyl-5,6-dihydropyrrin-1-carboxylate hydrobromide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-ethoxycarbonylmethyl-2,4-dimethylpyrrole (60730-22-5) → benzyl 13-(ethoxycarbonylmethyl)-3,8-diethyl-2,7,12,14-tetramethyl-5,6-dihydropyrrin-1-carboxylate hydrobromide (129715-49-7)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃ / CH₂Cl₂; diethyl ether / 0.5 h

2: 390 mg / 1.) trifluoroacetic acid, 2.) 30percent HBr / methanol; acetic acid / 1.) 1.5 h

With hydrogen bromide; trifluoroacetic acid; trichlorophosphate; In methanol; diethyl ether; dichloromethane; acetic acid;

Reference yield:

4-ethoxycarbonylmethyl-3,5-dimethylpyrrole-2-carboxylic acid (96096-21-8) → benzyl 13-(ethoxycarbonylmethyl)-3,8-diethyl-2,7,12,14-tetramethyl-5,6-dihydropyrrin-1-carboxylate hydrobromide (129715-49-7)

Guidance literature:

Multi-step reaction with 3 steps

1: trifluoroacetic acid / 0.5 h

2: POCl₃ / CH₂Cl₂; diethyl ether / 0.5 h

3: 390 mg / 1.) trifluoroacetic acid, 2.) 30percent HBr / methanol; acetic acid / 1.) 1.5 h

With hydrogen bromide; trifluoroacetic acid; trichlorophosphate; In methanol; diethyl ether; dichloromethane; acetic acid;

Reference yield:

4-ethoxycarbonylmethyl-3,5-dimethylpyrrole-2-carboxaldehyde (129689-56-1) + benzyl 5'-t-butoxycarbonyl-3,4'-diethyl-4,3'-dimethyl-2,2'-dipyrrylmethane-5-carboxylate (52459-98-0) → benzyl 13-(ethoxycarbonylmethyl)-3,8-diethyl-2,7,12,14-tetramethyl-5,6-dihydropyrrin-1-carboxylate hydrobromide (129715-49-7)

Guidance literature:

With hydrogen bromide; trifluoroacetic acid; In methanol; acetic acid; 1.) 1.5 h;

upstream raw materials:

4-ethoxycarbonylmethyl-3,5-dimethylpyrrole-2-carboxaldehyde

benzyl 5'-t-butoxycarbonyl-3,4'-diethyl-4,3'-dimethyl-2,2'-dipyrrylmethane-5-carboxylate

3-ethoxycarbonylmethyl-2,4-dimethylpyrrole

4-ethoxycarbonylmethyl-3,5-dimethylpyrrole-2-carboxylic acid