(1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol

Base Information

Chemical Name:(1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol
CAS No.:1326613-32-4
Molecular Formula:C₃₀H₅₀O₄
Molecular Weight:474.725
Hs Code.:

(1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol

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Chemical Property of (1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol

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Technology Process of (1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol

There total 8 articles about (1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1326613-48-2
C₄₂H₇₈O₄Si₂

: 1326613-32-4
(1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol

Guidance literature:: With hydrogen fluoride; In water; acetonitrile; at 0 ℃; for 0.166667h; Inert atmosphere;
DOI:10.3987/COM-11-12189

Reference yield:

: 1326613-40-4
3-((S)-1-((R)-oxiran-2-yl)but-3-enyloxy)propyl pivalate

: 1326613-32-4
(1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol

Guidance literature:: Multi-step reaction with 5 steps

1.1: n-butyllithium / tetrahydrofuran; hexane / 4 h / -78 °C / Inert atmosphere

1.2: -78 - 20 °C / Inert atmosphere

2.1: sodium hydroxide / methanol / 8 h / 20 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 9 h / -40 °C / Inert atmosphere

4.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 22 h / Reflux; Inert atmosphere

5.1: hydrogen fluoride / water; acetonitrile / 0.17 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; hydrogen fluoride; triethylamine; sodium hydroxide; In tetrahydrofuran; methanol; hexane; dichloromethane; water; toluene; acetonitrile; 4.1: Trost's coupling;
DOI:10.3987/COM-11-12189

Reference yield:

: 1326613-41-5
3-((4S,5R)-5-hydroxy-8-(trimethylsilyl)oct-1-en-7-yn-4-yloxy)propyl pivalate

: 1326613-32-4
(1R,2S,5Z)-2-(3-hydroxypropoxy)-5-((E)-2-(1R,3aS,7aR)-hexahydro-1-((R)-6-hydroxy-6-methylheptan-2-yl)-7a-methyl-1H-inden-4(7aH)-ylidene)ethylidene-4-methylenecyclohexanol

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydroxide / methanol / 8 h / 20 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 9 h / -40 °C / Inert atmosphere

3.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethylamine / toluene / 22 h / Reflux; Inert atmosphere

4.1: hydrogen fluoride / water; acetonitrile / 0.17 h / 0 °C / Inert atmosphere

With 2,6-dimethylpyridine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; hydrogen fluoride; triethylamine; sodium hydroxide; In methanol; dichloromethane; water; toluene; acetonitrile; 3.1: Trost's coupling;
DOI:10.3987/COM-11-12189