(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile sulfate

Base Information

Chemical Name:(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile sulfate
CAS No.:1092939-16-6
Molecular Formula:C17H18N6.H2SO4
Molecular Weight:404.44
Hs Code.:
Mol file:1092939-16-6.mol

Synonyms:(betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile sulfate;

Suppliers and Price of (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile sulfate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
Ruxolitinibsulfate 98+%
50mg
$ 207.00

Crysdot
Ruxolitinibsulfate 98+%
10mg
$ 90.00

Crysdot
Ruxolitinibsulfate 98+%
5mg
$ 56.00

Crysdot
Ruxolitinibsulfate 98+%
100mg
$ 371.00

Chemenu
(R)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrilesulfate 98%
100mg
$ 347.00

Total 9 raw suppliers

Chemical Property of (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile sulfate

Chemical Property:

PSA：166.16000
LogP:3.89438

Purity/Quality:

97% ^*data from raw suppliers

Ruxolitinibsulfate 98+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile sulfate

There total 5 articles about (betaR)-beta-Cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazole-1-propanenitrile sulfate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 941678-49-5,941685-37-6
ruxolitinib

: 1092939-16-6
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile sulfuric acid

Guidance literature:: With sulfuric acid; In acetonitrile; at 20 ℃; for 2h; Heating / reflux;

Reference yield:

: 941685-40-1
(3R)-3-cyclopentyl-3-[4-(7-[2-(trimethylsilyl)ethoxy]methyl-7H-pyrrolo[2,3-d]-pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile

: 1092939-16-6
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile sulfuric acid

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid / dichloromethane / 6 h

2: sulfuric acid / acetonitrile / 20 °C / Heating

With sulfuric acid; trifluoroacetic acid; In dichloromethane; acetonitrile;

Reference yield:

: 941685-27-4
4-(1H-pyrazol-4-yl)-7-((2-trimethylsilanylethoxy)methyl)-7H-pyrrolo[2,3-d]pyrimidine

: 1092939-16-6
(3R)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile sulfuric acid

Guidance literature:: Multi-step reaction with 4 steps

1: 1,8-diazabicyclo[5.4.0]undec-7-ene / acetonitrile / 20 °C

2: ethanol; hexane / Resolution of racemate

3: trifluoroacetic acid / dichloromethane / 6 h

4: sulfuric acid / acetonitrile / 20 °C / Heating

With sulfuric acid; 1,8-diazabicyclo[5.4.0]undec-7-ene; trifluoroacetic acid; In ethanol; hexane; dichloromethane; acetonitrile;