(S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester

Base Information

Chemical Name:(S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester
CAS No.:131010-66-7
Molecular Formula:C₂₆H₃₄N₆O₆
Molecular Weight:526.593
Hs Code.:

(S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester

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Chemical Property of (S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester

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Technology Process of (S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester

There total 6 articles about (S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 130985-85-2
1,3-diamino-9-benzyl-6-chloro-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine

: 131010-66-7,131100-23-7
(S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1: 74 percent / H₂, conc. HCl/H₂O/i-PrOH / 10percent Pd/C / 6 h / 760 Torr / Ambient temperature

2: H₂ / Pt₂O / trifluoroacetic acid; H₂O / 24 h / 2585.7 Torr / Ambient temperature

3: 78.5 percent / K₂CO₃ / dimethylsulfoxide / 10 h / 120 °C

4: trifluoroacetic acid (TFA) / 1.5 h / Ambient temperature

With hydrogenchloride; water; hydrogen; potassium carbonate; isopropyl alcohol; trifluoroacetic acid; palladium on activated charcoal; Adam’s catalyst; In water; dimethyl sulfoxide; trifluoroacetic acid;
DOI:10.1021/jm00106a022

Reference yield:

: 130985-83-0
3-amino-1-oxo-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridine hydrochloride

: 131010-66-7,131100-23-7
(S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: H₂ / Pt₂O / trifluoroacetic acid; H₂O / 24 h / 2585.7 Torr / Ambient temperature

2: 78.5 percent / K₂CO₃ / dimethylsulfoxide / 10 h / 120 °C

3: trifluoroacetic acid (TFA) / 1.5 h / Ambient temperature

With hydrogen; potassium carbonate; trifluoroacetic acid; Adam’s catalyst; In water; dimethyl sulfoxide; trifluoroacetic acid;
DOI:10.1021/jm00106a022

Reference yield:

: 130985-84-1
1,3-diamino-9-benzyl-7,8,9,10-tetrahydropyrimido<4,5-c><2,6>naphthyridin-6(5H,9H)-one hydrochloride

: 131010-66-7,131100-23-7
(S)-2-[4-(2-Amino-4-oxo-4,4b,5,7,8,8a,9,10-octahydro-3H-1,3,6,10-tetraaza-phenanthren-6-yl)-benzoylamino]-pentanedioic acid diethyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) DMF/SOCl₂, 2.) 50percent EtOH/H₂O / 1.) CHCl₃, reflux, 5 h, 2.) RT 24 h

2: 74 percent / H₂, conc. HCl/H₂O/i-PrOH / 10percent Pd/C / 6 h / 760 Torr / Ambient temperature

3: H₂ / Pt₂O / trifluoroacetic acid; H₂O / 24 h / 2585.7 Torr / Ambient temperature

4: 78.5 percent / K₂CO₃ / dimethylsulfoxide / 10 h / 120 °C

5: trifluoroacetic acid (TFA) / 1.5 h / Ambient temperature

With hydrogenchloride; thionyl chloride; ethanol; water; hydrogen; potassium carbonate; N,N-dimethyl-formamide; isopropyl alcohol; trifluoroacetic acid; palladium on activated charcoal; Adam’s catalyst; In water; dimethyl sulfoxide; trifluoroacetic acid;
DOI:10.1021/jm00106a022