AMG-208

Base Information

• Chemical Name: AMG-208
• CAS No.: 1002304-34-8
• Molecular Formula: C22H17N5O2
• Molecular Weight: 383.4
• Mol file: 1002304-34-8.mol

Synonyms:AMG 208

Chemical Property of AMG-208

Chemical Property:

• PKA: 5.98±0.27(Predicted)
• PSA: 74.43000
• Density: 1.34 g/cm³
• LogP: 3.92710
• Solubility.: insoluble in EtOH; insoluble in H2O; ≥3.83 mg/mL in DMSO

Purity/Quality:

98% ^*data from raw suppliers

amg208 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of AMG-208

There total 2 articles about AMG-208 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-((6-chloro-[1,2,4]triazolopyridazin-3-yl)methoxy)-7-methoxyquinoline (1002308-57-7) + phenylboronic acid (98-80-6) → 7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline (1002304-34-8)

Guidance literature:

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; tri tert-butylphosphoniumtetrafluoroborate; In 1,4-dioxane; water; at 80 ℃; for 3h;

DOI:10.1021/jm800043g

Reference yield:

→ 7-methoxy-4-((6-phenyl-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)methoxy)quinoline (1002304-34-8)

Guidance literature:

upstream raw materials:

4-((6-chloro-[1,2,4]triazolopyridazin-3-yl)methoxy)-7-methoxyquinoline

phenylboronic acid

Refernces

• 1、 Albrecht, Brian K.,Harmange, Jean-Christophe,Bauer, David,Berry, Loren,Bode, Christiane,Boezio, Alessandro A.,Chen, April,Choquette, Deborah,Dussault, Isabelle,Fridrich, Cary,Hirai, Satoko,Hoffman, Doug,Larrow, Jay F.,Kaplan-Lefko, Paula,Lin, Jasmine,Lohman, Julia,Long, Alexander M.,Moriguchi, Jodi,O'Connor, Anne,Potashman, Michele H.,Reese, Monica,Rex, Karen,Siegmund, Aaron,Shah, Kavita,Shimanovich, Roman,Springer, Stephanie K.,Teffera, Yohannes,Yang, Yajing,Zhang, Yihong,Bellon, Steven F.. "Discovery and optimization of triazolopyridazines as potent and selective inhibitors of the c-Met kinase". supporting information; experimental part. p. 2879 - 2882. Retrieved 2009/05/30.