AZD-8055

Base Information

Chemical Name:AZD-8055
CAS No.:1009298-09-2
Molecular Formula:C₂₅H₃₁N₅O₄
Molecular Weight:465.552
Hs Code.:29335990
Mol file:1009298-09-2.mol

Synonyms:AZD 8055;[5-[2,4-Bis((3S)-3-methylmorpholin-4-yl)pyrido[2,3-d]pyrimidin-7-yl]-2-methoxyphenyl]methanol;

Suppliers and Price of AZD-8055

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
AZD8055
10mg
$ 425.00

TRC
AZD8055
200mg
$ 375.00

Matrix Scientific
(5-(2,4-Bis((S)-3-methylmorpholino)pyrido-[2,3-d]pyrimidin-7-yl)-2-methoxyphenyl)methanol 95+%
250mg
$ 1853.00

DC Chemicals
AZD-8055 >98%
250 mg
$ 800.00

Crysdot
AZD-8055 98+%
50mg
$ 216.00

Crysdot
AZD-8055 98+%
100mg
$ 367.00

Crysdot
AZD-8055 98+%
250mg
$ 594.00

ChemScene
AZD-8055 99.19%
500mg
$ 876.00

ChemScene
AZD-8055 99.19%
1g
$ 1550.00

ChemScene
AZD-8055 99.19%
200mg
$ 396.00

Total 58 raw suppliers

Chemical Property of AZD-8055

Chemical Property:

Boiling Point:694.302 °C at 760 mmHg
PKA:14.20±0.10(Predicted)
Flash Point:373.701 °C
PSA：93.07000
Density:1.248 g/cm³
LogP:2.77290
Storage Temp.:-20°C
Solubility.:Soluble in DMSO (up to 30 mg/ml)

Purity/Quality:

99%, ^*data from raw suppliers

AZD8055 ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Safety Statements: 24/25

MSDS Files:: SDS file from LookChem

Useful:

Description AZD8055 (1009298-09-2) is a potent and highly selective inhibitor of mammalian target of rapamycin kinase (mTOR) kinase (IC50 = 0.8 nM).1,2 ?mTOR acts as a nutrient/energy/redox sensor and a controller of protein synthesis – as such it is a very important target for cancer research.? It has been investigated as a potential chemotherapeutic for various cancers.3-7
Uses A novel ATP-competitive inhibitor of mTOR with an IC50 of 0.8 nM. A potent, selective, and orally bioavailable ATP-competitive mTOR kinase inhibitor with an IC50 of 0.8 nM. It inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1 as well as phosphoryla tion of the mTORC2 substrate AKT and downstream proteins. The rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1 were fully inhibited by AZD8055, resulting in significant inhibition of cap-dep endent translation. In vitro, AZD8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells. In vivo, AZD8055 induces a dose-dependent pharmacodynamic effect on phosphorylated S 6 and phosphorylated AKT at plasma concentrations leading to tumor growth inhibition.

Technology Process of AZD-8055

There total 10 articles about AZD-8055 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 64321-24-0
2-amino-6-chloro-pyridine-3-carboxamide

: 1009298-09-2
AZD₈₀₅₅

Guidance literature:: Multi-step reaction with 5 steps

1: toluene / 115 °C

2: trichlorophosphate; N-ethyl-N,N-diisopropylamine / toluene / 100 °C

3: N-ethyl-N,N-diisopropylamine / dichloromethane / 0 - 20 °C

4: N-ethyl-N,N-diisopropylamine / N,N-dimethyl acetamide / 70 °C

5: tetrakis(triphenylphosphine) palladium⁽⁰⁾

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl acetamide; toluene;
DOI:10.1016/j.bmcl.2013.01.019

Reference yield:

: 1009303-44-9
(3S)-4-[7-chloro-2-[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d] pyrimidin-4-yl] 3-methyl-morpholine

: 1009303-77-8
[2-methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]methanol

: 1009298-09-2
AZD₈₀₅₅

Guidance literature:: With sodium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; toluene; at 140 ℃; for 0.5h; Microwave radiation;

Reference yield:

: 1009298-82-1
methyl 5-{2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxybenzoate

: 1009298-09-2
AZD₈₀₅₅

Guidance literature:: methyl 5-{2,4-bis[(3S)-3-methylmorpholin-4-yl]pyrido[2,3-d]pyrimidin-7-yl}-2-methoxybenzoate; With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 16h; Inert atmosphere;

With water; In tetrahydrofuran;