5'-O-trityl-3'-deoxycytidine

Base Information

Chemical Name:5'-O-trityl-3'-deoxycytidine
CAS No.:130860-13-8
Molecular Formula:C₂₈H₂₇N₃O₄
Molecular Weight:469.54
Hs Code.:

Synonyms:

Suppliers and Price of 5'-O-trityl-3'-deoxycytidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 5'-O-trityl-3'-deoxycytidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 5'-O-trityl-3'-deoxycytidine

There total 8 articles about 5'-O-trityl-3'-deoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4-Amino-1-[(2R,3R,5S)-3-(tert-butyl-dimethyl-silanyloxy)-5-trityloxymethyl-tetrahydro-furan-2-yl]-1H-pyrimidin-2-one

: 130860-13-8
5'-O-trityl-3'-deoxycytidine

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm00106a034

Reference yield:

: 76-83-5
trityl chloride

: 130860-13-8
5'-O-trityl-3'-deoxycytidine

Guidance literature:: Multi-step reaction with 7 steps

1: 79 percent / pyridine / 1.) RT, overnight, 2.) 100 deg C, 4 h

2: 57 percent / AgNO₃, pyridine / tetrahydrofuran / 72 h / Ambient temperature

3: 83 percent / 4-(dimethylamino)pyridine / acetonitrile / 65 h / Ambient temperature

4: 56 percent / 2,2'-azobis(2-methylpropionitrile) (AIBN), n-Bu₃SnH / toluene / 3 h / 110 - 120 °C

5: 4-chlorophenyl phosphorodichloridate, pyridine / 48 h / Ambient temperature

6: NH₄OH / dioxane / 3 h / Ambient temperature

7: tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; dmap; ammonium hydroxide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; silver nitrate; 4-chlorophenylphosphorodichloridate; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile;
DOI:10.1021/jm00106a034

Reference yield:

: 117136-35-3
2'-O-(tert-butyldimethylsilyl)-5'-O-(triphenylmethyl)uridine

: 130860-13-8
5'-O-trityl-3'-deoxycytidine

Guidance literature:: Multi-step reaction with 5 steps

1: 83 percent / 4-(dimethylamino)pyridine / acetonitrile / 65 h / Ambient temperature

2: 56 percent / 2,2'-azobis(2-methylpropionitrile) (AIBN), n-Bu₃SnH / toluene / 3 h / 110 - 120 °C

3: 4-chlorophenyl phosphorodichloridate, pyridine / 48 h / Ambient temperature

4: NH₄OH / dioxane / 3 h / Ambient temperature

5: tetra-n-butylammonium fluoride / tetrahydrofuran / 1 h / Ambient temperature

With pyridine; dmap; ammonium hydroxide; 2,2'-azobis(isobutyronitrile); tetrabutyl ammonium fluoride; tri-n-butyl-tin hydride; 4-chlorophenylphosphorodichloridate; In tetrahydrofuran; 1,4-dioxane; toluene; acetonitrile;
DOI:10.1021/jm00106a034