(S)-Ranolazine

Base Information

• Chemical Name: (S)-Ranolazine
• CAS No.: 114246-81-0
• Molecular Formula: C₂₄H₃₃N₃O₄
• Molecular Weight: 427.544
• Mol file: 114246-81-0.mol

Synonyms:

Chemical Property of (S)-Ranolazine

Chemical Property:

Purity/Quality:

≥95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-Ranolazine

There total 6 articles about (S)-Ranolazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C26H35N3O5 → (S)-Ranolazine (114246-81-0,142387-99-3)

Guidance literature:

With potassium carbonate; In water; at 30 ℃; for 2h;

DOI:10.1039/c6ra06879k

Reference yield:

Ranolazine (95635-55-5,142387-99-3) → (S)-Ranolazine (114246-81-0,142387-99-3) + (R)-Ranolazine (142387-99-3)

Guidance literature:

With nanocellulose derivative/silica hybrid core-shell slurry-packed stainless steel column; In hexane; chloroform; isopropyl alcohol; at 25 ℃; Reagent/catalyst; Solvent; Resolution of racemate;

DOI:10.3390/molecules21050561

Reference yield:

2,6-dimethylaniline (87-62-7) → (S)-Ranolazine (114246-81-0,142387-99-3)

Guidance literature:

Multi-step reaction with 6 steps

1: dichloromethane / 4 h / 4 °C

2: methanol / 4 h / 60 °C

3: sodium dodecyl-sulfate / water / 12 h / 15 °C / Green chemistry

4: potassium carbonate / water / Green chemistry

5: Candida antartica lipase in the form of CLEA / toluene / 48 h / 37 °C

6: potassium carbonate / water / 2 h / 30 °C

With Candida antartica lipase in the form of CLEA; sodium dodecyl-sulfate; potassium carbonate; In methanol; dichloromethane; water; toluene;

DOI:10.1039/c6ra06879k

upstream raw materials:

2-chloro-N-(2,6-dimethylphenyl)acetamide

2,6-dimethylaniline

N-(2,6-dimethylphenyl)-2-(piperazin-1-yl)acetamide

(RS)-2-(4-(3-chloro-2-hydroxyphenyl)piperazin-1-yl)-N-(2,6-dimethylphenyl)acetamide