Technology Process of (2S,12S)-(-)-7,7-bis(2-propenyl)-4,10-dioxatridecane-2,12-diol di-p-tosylate
There total 8 articles about (2S,12S)-(-)-7,7-bis(2-propenyl)-4,10-dioxatridecane-2,12-diol di-p-tosylate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 8 steps
1: 93 percent / LiAlH4 / diethyl ether / 12 h / Heating
2: 97 percent / KOH / tetrahydrofuran / a) 0 deg C, 2 h, b) RT, 4 h
3: 48 percent / dimethylsulfoxide / 18 h / 75 °C
4: 96 percent / 35 percent aq. NaOH / methanol / 14 h / Heating
5: 94 percent / LiAlH4 / diethyl ether / 1 h / 0 - 20 °C
6: 1.) KO-t-Bu, HMPA / 1.) 5 min, 2.) RT, 1 d
7: Amberlite IR-120 (H+ form), MeOH / 24 h / Ambient temperature
8: 94 percent / pyridine / 24 h / Ambient temperature
With
pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; Amberlite IR-120 (H+ form); potassium tert-butylate;
In
tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(99)00287-6
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 97 percent / KOH / tetrahydrofuran / a) 0 deg C, 2 h, b) RT, 4 h
2: 48 percent / dimethylsulfoxide / 18 h / 75 °C
3: 96 percent / 35 percent aq. NaOH / methanol / 14 h / Heating
4: 94 percent / LiAlH4 / diethyl ether / 1 h / 0 - 20 °C
5: 1.) KO-t-Bu, HMPA / 1.) 5 min, 2.) RT, 1 d
6: Amberlite IR-120 (H+ form), MeOH / 24 h / Ambient temperature
7: 94 percent / pyridine / 24 h / Ambient temperature
With
pyridine; methanol; N,N,N,N,N,N-hexamethylphosphoric triamide; potassium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; Amberlite IR-120 (H+ form); potassium tert-butylate;
In
tetrahydrofuran; methanol; diethyl ether; dimethyl sulfoxide;
DOI:10.1016/S0957-4166(99)00287-6
