(4aR,6R,7R,7aS)-6-{8-Benzylsulfanyl-6-[(furan-2-ylmethyl)-amino]-purin-9-yl}-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol

Base Information

• Chemical Name: (4aR,6R,7R,7aS)-6-{8-Benzylsulfanyl-6-[(furan-2-ylmethyl)-amino]-purin-9-yl}-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol
• CAS No.: 118182-87-9
• Molecular Formula: C₂₂H₂₂N₅O₇PS
• Molecular Weight: 531.486

Synonyms:

Chemical Property of (4aR,6R,7R,7aS)-6-{8-Benzylsulfanyl-6-[(furan-2-ylmethyl)-amino]-purin-9-yl}-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of (4aR,6R,7R,7aS)-6-{8-Benzylsulfanyl-6-[(furan-2-ylmethyl)-amino]-purin-9-yl}-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol

There total 3 articles about (4aR,6R,7R,7aS)-6-{8-Benzylsulfanyl-6-[(furan-2-ylmethyl)-amino]-purin-9-yl}-2-oxo-tetrahydro-2λ⁵-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(4aR,6R,7R,7aS)-6-(8-Benzylsulfanyl-6-{[1-furan-2-yl-meth-(Z)-ylidene]-amino}-purin-9-yl)-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol → (4aR,6R,7R,7aS)-6-{8-Benzylsulfanyl-6-[(furan-2-ylmethyl)-amino]-purin-9-yl}-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol (118182-87-9)

Guidance literature:

With sodium cyanoborohydride; In acetic acid; for 6h; Yield given; Ambient temperature;

DOI:10.1248/cpb.36.2212

Reference yield:

furfural (98-01-1) → (4aR,6R,7R,7aS)-6-{8-Benzylsulfanyl-6-[(furan-2-ylmethyl)-amino]-purin-9-yl}-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol (118182-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tri-n-butylamine / acetic acid / 0.5 h / Ambient temperature

2: sodium cyanoborohydride / acetic acid / 6 h / Ambient temperature

With tributyl-amine; sodium cyanoborohydride; In acetic acid;

DOI:10.1248/cpb.36.2212

Reference yield:

8-benzylthioadenosine 3',5'-cyclic phosphate (32487-38-0) → (4aR,6R,7R,7aS)-6-{8-Benzylsulfanyl-6-[(furan-2-ylmethyl)-amino]-purin-9-yl}-2-oxo-tetrahydro-2λ5-furo[3,2-d][1,3,2]dioxaphosphinine-2,7-diol (118182-87-9)

Guidance literature:

Multi-step reaction with 2 steps

1: tri-n-butylamine / acetic acid / 0.5 h / Ambient temperature

2: sodium cyanoborohydride / acetic acid / 6 h / Ambient temperature

With tributyl-amine; sodium cyanoborohydride; In acetic acid;

DOI:10.1248/cpb.36.2212

upstream raw materials:

furfural

8-benzylthioadenosine 3',5'-cyclic phosphate

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