(S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid

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Chemical Name:(S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid
CAS No.:105611-68-5
Molecular Formula:C₄₈H₇₃N₁₁O₁₀S
Molecular Weight:996.241
Hs Code.:

(S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid

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Chemical Property of (S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid

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Technology Process of (S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid

There total 3 articles about (S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 115527-78-1
[(S)-1-(8-Amino-octylcarbamoyl)-2-phenyl-ethyl]-carbamic acid 9H-fluoren-9-ylmethyl ester

: 105611-68-5
(S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid

Guidance literature:: Multi-step reaction with 3 steps

1: 89 percent / dimethylformamide / rt, then 40 deg C

2: 83 percent / Zn, AcOH / Ambient temperature

3: solid phase synthesis; the next amino acids are: Glu(OtBu)-OObt ester, BOC-Met(O₂)-OObt ester

With acetic acid; zinc; In N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)96803-5

Reference yield:

: 115527-79-2
(4-{8-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-octylcarbamoyloxymethyl}-phenoxy)-acetic acid 2-oxo-2-phenyl-ethyl ester

: 105611-68-5
(S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / Zn, AcOH / Ambient temperature

2: solid phase synthesis; the next amino acids are: Glu(OtBu)-OObt ester, BOC-Met(O₂)-OObt ester

With acetic acid; zinc;
DOI:10.1016/S0040-4039(00)96803-5

Reference yield:

: Phe-OObt ester

: D-Lys(BOC)-OObt ester

: His(Trt)-OObt ester

: 115527-80-5
(4-{8-[(S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionylamino]-octylcarbamoyloxymethyl}-phenoxy)-acetic acid

: 105611-68-5
(S)-4-[(S)-1-((S)-1-{(S)-5-Amino-1-[(S)-1-(8-amino-octylcarbamoyl)-2-phenyl-ethylcarbamoyl]-pentylcarbamoyl}-2-phenyl-ethylcarbamoyl)-2-(1H-imidazol-4-yl)-ethylcarbamoyl]-4-((S)-2-amino-4-methanesulfonyl-butyrylamino)-butyric acid

Guidance literature:: Multistep reaction; solid phase synthesis; the next amino acids are: Glu(OtBu)-OObt ester, BOC-Met(O₂)-OObt ester;
DOI:10.1016/S0040-4039(00)96803-5