(gammaR)-gamma-Amino-4-bromobenzenepropanol

Base Information

• Chemical Name: (gammaR)-gamma-Amino-4-bromobenzenepropanol
• CAS No.: 1213037-93-4
• Molecular Formula: C9H12BrNO
• Molecular Weight: 230.10
• Hs Code.: 2922498590
• Mol file: 1213037-93-4.mol

Synonyms:(3R)-3-Amino-3-(4-bromophenyl)propan-1-ol;Benzenepropanol, gamma-amino-4-bromo-, (gammaR)-;

Chemical Property of (gammaR)-gamma-Amino-4-bromobenzenepropanol

Chemical Property:

• Boiling Point: 348.6 °C at 760 mmHg
• PKA: 14.87±0.10(Predicted)
• Flash Point: 164.6 °C
• PSA: 46.25000
• Density: 1.466g/cm³
• LogP: 2.53160
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

(R)-3-Amino-3-(4-bromophenyl)propan-1-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (gammaR)-gamma-Amino-4-bromobenzenepropanol

There total 5 articles about (gammaR)-gamma-Amino-4-bromobenzenepropanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.5%

(S)-3-amino-3-(4-bromophenyl)propionic acid (275826-36-3,295356-30-8) → (S)-3-amino-3-(4-bromophenyl)propan-1-ol (1143534-62-6,1213037-93-4)

Guidance literature:

(S)-3-amino-3-(4-bromophenyl)propionic acid; With borane-THF; In tetrahydrofuran; at 0 - 22 ℃; for 30h;

With sodium hydroxide; water; In dichloromethane;

Reference yield:

3-amino-3-(4'-bromophenyl)propanoic acid (39773-47-2,295356-30-8) → 3-amino-3-(4-bromophenyl)propan-1-ol (787615-14-9,1213037-93-4)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 5.5h; Inert atmosphere; Reflux;

DOI:10.1016/j.tet.2020.131064

Reference yield:

C11H11BrCl3NO → 3-amino-3-(4-bromophenyl)propan-1-ol (787615-14-9,1213037-93-4)

Guidance literature:

Multi-step reaction with 2 steps

1: cesium iodide; phthaloyl peroxide / acetonitrile / 8 h / Irradiation; Inert atmosphere

2: hydrogenchloride / methanol; water / 2 h

With hydrogenchloride; phthaloyl peroxide; cesium iodide; In methanol; water; acetonitrile;

DOI:10.1002/anie.202008806

upstream raw materials:

(S)-3-amino-3-(4-bromophenyl)propionic acid

4-bromo-benzaldehyde

3-amino-3-(4'-bromophenyl)propanoic acid

Downstream raw materials:

tert- butyl (R)-(1-(4-bromophenyl)-3-hydroxypropyl)carbamate

Refernces

• 1、 Fang, Yuanding,Fu, Kang,Shi, Lei,Zhao, Rong,Zhou, Jia. "Site-Specific C(sp3)–H Aminations of Imidates and Amidines Enabled by Covalently Tethered Distonic Radical Anions". . p. 20682 - 20690. Retrieved 2020/09/07.