1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-mercapto-2-oxo-tetrahydro-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione

Base Information

• Chemical Name: 1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-mercapto-2-oxo-tetrahydro-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione
• CAS No.: 274905-53-2
• Molecular Formula: C₃₀H₂₉N₂O₉PS
• Molecular Weight: 624.608

Synonyms:

Chemical Property of 1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-mercapto-2-oxo-tetrahydro-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-mercapto-2-oxo-tetrahydro-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione

There total 5 articles about 1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-mercapto-2-oxo-tetrahydro-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-oxo-tetrahydro-2λ5-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione (274905-49-6) → 1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-mercapto-2-oxo-tetrahydro-2λ5-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione (274905-53-2)

Guidance literature:

With sulfur; In carbon disulfide;

DOI:10.1016/S0960-894X(00)00700-9

Reference yield:

5'-dimethoxytrityluridine (81246-79-9) → 1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-mercapto-2-oxo-tetrahydro-2λ5-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione (274905-53-2)

Guidance literature:

Multi-step reaction with 2 steps

1: diphenyl H-phosphonate; pyridine / dimethylformamide / 0.33 h

2: S₈ / CS₂

With pyridine; sulfur; diphenyl hydrogen phosphite; In carbon disulfide; N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(00)00700-9

Reference yield:

sulfur (7704-34-9) + 1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-oxo-tetrahydro-2λ5-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione (274905-49-6) → 1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-mercapto-2-oxo-tetrahydro-2λ5-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione (274905-53-2)

Guidance literature:

With pyridine; In 1-ethyl-3-methylimidazol-3-ium ethyl sulfate; at 18 ℃; Ionic liquid;

upstream raw materials:

1-{(3aR,4R,6R,6aR)-6-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-2-oxo-tetrahydro-2λ⁵-furo[3,4-d][1,3,2]dioxaphosphol-4-yl}-1H-pyrimidine-2,4-dione

5'-dimethoxytrityluridine

sulfur

uridine

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